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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

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Title: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Authors: van der Lee SJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl.; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl., Conway OJ; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Jansen I; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Carrasquillo MM; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Kleineidam L; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., van den Akker E; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands., Hernández I; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., van Eijk KR; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands., Stringa N; Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Chen JA; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, USA., Zettergren A; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Andlauer TFM; Max Planck Institute of Psychiatry, Munich, Germany.; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany., Diez-Fairen M; Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain.; Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Barcelona, Spain., Simon-Sanchez J; German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany.; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Lleó A; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Zetterberg H; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK., Nygaard M; The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark., Blauwendraat C; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-3707, USA., Savage JE; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Mengel-From J; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark., Moreno-Grau S; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Wagner M; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany., Fortea J; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Keogh MJ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Blennow K; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Skoog I; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Friese MA; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany., Pletnikova O; Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA., Zulaica M; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Biodonostia, San Sebastian, Spain., Lage C; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; University Hospital 'Marques de Valdecilla', Santander, Spain.; IDIVAL, Santander, Spain., de Rojas I; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany., Illán-Gala I; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Wei W; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Jeune B; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark., Orellana A; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Then Bergh F; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Department of Neurology, University of Leipzig, Leipzig, Germany., Wang X; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Hulsman M; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands., Beker N; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Tesi N; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands., Morris CM; Newcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK., Indakoetxea B; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Biodonostia, San Sebastian, Spain.; Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain., Collij LE; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Scherer M; Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany., Morenas-Rodríguez E; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Ironside JW; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK., van Berckel BNM; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Alcolea D; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Wiendl H; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie, University of Münster, Münster, Germany., Strickland SL; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Pastor P; Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain.; Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Barcelona, Spain., Rodríguez Rodríguez E; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; University Hospital 'Marques de Valdecilla', Santander, Spain.; IDIVAL, Santander, Spain., Boeve BF; Department of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA., Petersen RC; Department of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA., Ferman TJ; Department of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., van Gerpen JA; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Reinders MJT; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands., Uitti RJ; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Tárraga L; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Maier W; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany., Dols-Icardo O; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Kawalia A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Dalmasso MC; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina., Boada M; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Zettl UK; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Department of Neurology, University of Rostock, Rostock, Germany., van Schoor NM; Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Beekman M; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Allen M; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Masliah E; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., de Munain AL; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Biodonostia, San Sebastian, Spain.; Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain., Pantelyat A; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, 21287, USA., Wszolek ZK; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Ross OA; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Dickson DW; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Knopman D; Department of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA., Rademakers R; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Lemstra AW; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Pijnenburg YAL; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Gasser T; Center of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany., Chinnery PF; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK., Hemmer B; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Huisman MA; Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Department of Sociology, VU University, Amsterdam, The Netherlands., Troncoso J; Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA., Moreno F; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Biodonostia, San Sebastian, Spain.; Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain., Nohr EA; Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Sørensen TIA; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK., Heutink P; German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany.; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Sánchez-Juan P; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; University Hospital 'Marques de Valdecilla', Santander, Spain.; IDIVAL, Santander, Spain., Posthuma D; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Clarimón J; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain., Christensen K; The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA., Scholz SW; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-3707, USA.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, 21287, USA., Ramirez A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Ruiz A; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Slagboom E; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Dutch Society for Research on Ageing, Leiden, The Netherlands., van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Holstege H; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. h.holstege@amsterdamumc.nl.; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. h.holstege@amsterdamumc.nl.
Corporate Authors: DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB), GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group
Source: Acta neuropathologica [Acta Neuropathol] 2019 Aug; Vol. 138 (2), pp. 237-250. Date of Electronic Publication: 2019 May 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22van+der+Lee+SJ%22">van der Lee SJ</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl.; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Conway+OJ%22">Conway OJ</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Jansen+I%22">Jansen I</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Carrasquillo+MM%22">Carrasquillo MM</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Kleineidam+L%22">Kleineidam L</searchLink>; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22van+den+Akker+E%22">van den Akker E</searchLink>; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hernández+I%22">Hernández I</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22van+Eijk+KR%22">van Eijk KR</searchLink>; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Stringa+N%22">Stringa N</searchLink>; Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chen+JA%22">Chen JA</searchLink>; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, USA.<br /><searchLink fieldCode="AU" term="%22Zettergren+A%22">Zettergren A</searchLink>; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Andlauer+TFM%22">Andlauer TFM</searchLink>; Max Planck Institute of Psychiatry, Munich, Germany.; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Diez-Fairen+M%22">Diez-Fairen M</searchLink>; Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain.; Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Simon-Sanchez+J%22">Simon-Sanchez J</searchLink>; German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany.; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Lleó+A%22">Lleó A</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.<br /><searchLink fieldCode="AU" term="%22Nygaard+M%22">Nygaard M</searchLink>; The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Blauwendraat+C%22">Blauwendraat C</searchLink>; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-3707, USA.<br /><searchLink fieldCode="AU" term="%22Savage+JE%22">Savage JE</searchLink>; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mengel-From+J%22">Mengel-From J</searchLink>; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Moreno-Grau+S%22">Moreno-Grau S</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wagner+M%22">Wagner M</searchLink>; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Fortea+J%22">Fortea J</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Keogh+MJ%22">Keogh MJ</searchLink>; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Skoog+I%22">Skoog I</searchLink>; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Friese+MA%22">Friese MA</searchLink>; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Pletnikova+O%22">Pletnikova O</searchLink>; Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zulaica+M%22">Zulaica M</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Biodonostia, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Lage+C%22">Lage C</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; University Hospital 'Marques de Valdecilla', Santander, Spain.; IDIVAL, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22de+Rojas+I%22">de Rojas I</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Riedel-Heller+S%22">Riedel-Heller S</searchLink>; Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Illán-Gala+I%22">Illán-Gala I</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wei+W%22">Wei W</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Jeune+B%22">Jeune B</searchLink>; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Orellana+A%22">Orellana A</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Then+Bergh+F%22">Then Bergh F</searchLink>; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Department of Neurology, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Hulsman+M%22">Hulsman M</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Beker+N%22">Beker N</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tesi+N%22">Tesi N</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Morris+CM%22">Morris CM</searchLink>; Newcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.<br /><searchLink fieldCode="AU" term="%22Indakoetxea+B%22">Indakoetxea B</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Biodonostia, San Sebastian, Spain.; Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Collij+LE%22">Collij LE</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Scherer+M%22">Scherer M</searchLink>; Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany.<br /><searchLink fieldCode="AU" term="%22Morenas-Rodríguez+E%22">Morenas-Rodríguez E</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ironside+JW%22">Ironside JW</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK.<br /><searchLink fieldCode="AU" term="%22van+Berckel+BNM%22">van Berckel BNM</searchLink>; Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Alcolea+D%22">Alcolea D</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wiendl+H%22">Wiendl H</searchLink>; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Strickland+SL%22">Strickland SL</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Pastor+P%22">Pastor P</searchLink>; Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain.; Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez+Rodríguez+E%22">Rodríguez Rodríguez E</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; University Hospital 'Marques de Valdecilla', Santander, Spain.; IDIVAL, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Boeve+BF%22">Boeve BF</searchLink>; Department of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+RC%22">Petersen RC</searchLink>; Department of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Ferman+TJ%22">Ferman TJ</searchLink>; Department of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22van+Gerpen+JA%22">van Gerpen JA</searchLink>; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Reinders+MJT%22">Reinders MJT</searchLink>; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Uitti+RJ%22">Uitti RJ</searchLink>; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Tárraga+L%22">Tárraga L</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Maier+W%22">Maier W</searchLink>; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Dols-Icardo+O%22">Dols-Icardo O</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kawalia+A%22">Kawalia A</searchLink>; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Dalmasso+MC%22">Dalmasso MC</searchLink>; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.; Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Boada+M%22">Boada M</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Zettl+UK%22">Zettl UK</searchLink>; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Department of Neurology, University of Rostock, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22van+Schoor+NM%22">van Schoor NM</searchLink>; Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Beekman+M%22">Beekman M</searchLink>; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Allen+M%22">Allen M</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Masliah+E%22">Masliah E</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22de+Munain+AL%22">de Munain AL</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Biodonostia, San Sebastian, Spain.; Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Pantelyat+A%22">Pantelyat A</searchLink>; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Wszolek+ZK%22">Wszolek ZK</searchLink>; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Ross+OA%22">Ross OA</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Dickson+DW%22">Dickson DW</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Graff-Radford+NR%22">Graff-Radford NR</searchLink>; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Knopman+D%22">Knopman D</searchLink>; Department of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Rademakers+R%22">Rademakers R</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Lemstra+AW%22">Lemstra AW</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pijnenburg+YAL%22">Pijnenburg YAL</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Scheltens+P%22">Scheltens P</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gasser+T%22">Gasser T</searchLink>; Center of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Chinnery+PF%22">Chinnery PF</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Hemmer+B%22">Hemmer B</searchLink>; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Huisman+MA%22">Huisman MA</searchLink>; Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Department of Sociology, VU University, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Troncoso+J%22">Troncoso J</searchLink>; Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Moreno+F%22">Moreno F</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Instituto Biodonostia, San Sebastian, Spain.; Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Nohr+EA%22">Nohr EA</searchLink>; Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+TIA%22">Sørensen TIA</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Heutink+P%22">Heutink P</searchLink>; German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany.; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Sánchez-Juan+P%22">Sánchez-Juan P</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; University Hospital 'Marques de Valdecilla', Santander, Spain.; IDIVAL, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Posthuma+D%22">Posthuma D</searchLink>; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Clarimón+J%22">Clarimón J</searchLink>; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Christensen+K%22">Christensen K</searchLink>; The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Ertekin-Taner+N%22">Ertekin-Taner N</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Scholz+SW%22">Scholz SW</searchLink>; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-3707, USA.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+A%22">Ramirez A</searchLink>; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ruiz+A%22">Ruiz A</searchLink>; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Slagboom+E%22">Slagboom E</searchLink>; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Dutch Society for Research on Ageing, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Flier+WM%22">van der Flier WM</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Holstege+H%22">Holstege H</searchLink>; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. h.holstege@amsterdamumc.nl.; Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. h.holstege@amsterdamumc.nl.
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  Data: <searchLink fieldCode="CA" term="%22DESGESCO+%28Dementia+Genetics+Spanish+Consortium%29%2C+EADB+%28Alzheimer+Disease+European+DNA+biobank%29%22">DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank)</searchLink><br /><searchLink fieldCode="CA" term="%22EADB+%28Alzheimer+Disease+European+DNA+biobank%29%22">EADB (Alzheimer Disease European DNA biobank)</searchLink><br /><searchLink fieldCode="CA" term="%22IFGC+%28International+FTD-Genomics+Consortium%29%2C+IPDGC+%28The+International+Parkinson+Disease+Genomics+Consortium%29%22">IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium)</searchLink><br /><searchLink fieldCode="CA" term="%22IPDGC+%28The+International+Parkinson+Disease+Genomics+Consortium%29%22">IPDGC (The International Parkinson Disease Genomics Consortium)</searchLink><br /><searchLink fieldCode="CA" term="%22RiMod-FTD+%28Risk+and+Modifying+factors+in+Fronto-Temporal+Dementia%29%22">RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia)</searchLink><br /><searchLink fieldCode="CA" term="%22Netherlands+Brain+Bank+%28NBB%29%22">Netherlands Brain Bank (NBB)</searchLink><br /><searchLink fieldCode="CA" term="%22GIFT+%28Genetic+Investigation+in+Frontotemporal+Dementia+and+Alzheimer%27s+Disease%29+Study+Group%22">GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2019 Aug; Vol. 138 (2), pp. 237-250. <i>Date of Electronic Publication: </i>2019 May 27.
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  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0412041 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0533 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200016322%22">00016322 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00401-019-02026-8
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        Text: English
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      – TitleFull: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
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    IsPartOfRelationships:
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          Dates:
            – D: 01
              M: 08
              Text: 2019 Aug
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-electronic
              Value: 1432-0533
          Numbering:
            – Type: volume
              Value: 138
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Acta neuropathologica
              Type: main
ResultId 1