Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.

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Title: Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.
Authors: Gibani MM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK. malick.gibani@paediatrics.ox.ac.uk.; Department of Medicine, Imperial College London, London, UK. malick.gibani@paediatrics.ox.ac.uk., Jones E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Barton A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Jin C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Meek J; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Camara S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Galal U; Nuffield Department of Primary Care Health Sciences, Clinical Trials Unit, University of Oxford, Oxford, UK., Heinz E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Rosenberg-Hasson Y; Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Obermoser G; Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Jones C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Campbell D; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Black C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Thomaides-Brears H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Darlow C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Dold C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Silva-Reyes L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Blackwell L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Lara-Tejero M; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Jiao X; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Stack G; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Blohmke CJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Hill J; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Angus B; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Dougan G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Department of Medicine, University of Cambridge, Hinxton, UK., Galán J; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Source: Nature medicine [Nat Med] 2019 Jul; Vol. 25 (7), pp. 1082-1088. Date of Electronic Publication: 2019 Jul 03.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gibani+MM%22">Gibani MM</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK. malick.gibani@paediatrics.ox.ac.uk.; Department of Medicine, Imperial College London, London, UK. malick.gibani@paediatrics.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Jones+E%22">Jones E</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Barton+A%22">Barton A</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jin+C%22">Jin C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Meek+J%22">Meek J</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Camara+S%22">Camara S</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Galal+U%22">Galal U</searchLink>; Nuffield Department of Primary Care Health Sciences, Clinical Trials Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Heinz+E%22">Heinz E</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Rosenberg-Hasson+Y%22">Rosenberg-Hasson Y</searchLink>; Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Obermoser+G%22">Obermoser G</searchLink>; Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jones+C%22">Jones C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+D%22">Campbell D</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Black+C%22">Black C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Thomaides-Brears+H%22">Thomaides-Brears H</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Darlow+C%22">Darlow C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dold+C%22">Dold C</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Silva-Reyes+L%22">Silva-Reyes L</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Blackwell+L%22">Blackwell L</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lara-Tejero+M%22">Lara-Tejero M</searchLink>; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Jiao+X%22">Jiao X</searchLink>; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Stack+G%22">Stack G</searchLink>; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Blohmke+CJ%22">Blohmke CJ</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hill+J%22">Hill J</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Angus+B%22">Angus B</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dougan+G%22">Dougan G</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Department of Medicine, University of Cambridge, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Galán+J%22">Galán J</searchLink>; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Pollard+AJ%22">Pollard AJ</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
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