Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.

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Title: Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Authors: Dekhne AS; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Shah K; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania., Ducker GS; Department of Chemistry/Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey., Katinas JM; Department of Chemistry, Indiana University, Bloomington, Indiana., Wong-Roushar J; Department of Chemistry, Indiana University, Bloomington, Indiana., Nayeen MJ; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania., Doshi A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania., Ning C; Biochemistry and Molecular Biology, Jilin University, Changchun, Jilin Province, China., Bao X; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Frühauf J; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Liu J; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan., Wallace-Povirk A; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., O'Connor C; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Dzinic SH; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., White K; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Kushner J; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Kim S; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Hüttemann M; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan., Polin L; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Rabinowitz JD; Department of Chemistry/Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey., Li J; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Hou Z; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Dann CE 3rd; Department of Chemistry, Indiana University, Bloomington, Indiana. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu., Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu., Matherly LH; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2019 Oct; Vol. 18 (10), pp. 1787-1799. Date of Electronic Publication: 2019 Jul 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-8514
DOI:10.1158/1535-7163.MCT-19-0037