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Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.

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Title: Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Authors: Dekhne AS; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Shah K; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania., Ducker GS; Department of Chemistry/Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey., Katinas JM; Department of Chemistry, Indiana University, Bloomington, Indiana., Wong-Roushar J; Department of Chemistry, Indiana University, Bloomington, Indiana., Nayeen MJ; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania., Doshi A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania., Ning C; Biochemistry and Molecular Biology, Jilin University, Changchun, Jilin Province, China., Bao X; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Frühauf J; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Liu J; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan., Wallace-Povirk A; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., O'Connor C; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Dzinic SH; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., White K; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Kushner J; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Kim S; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Hüttemann M; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan., Polin L; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Rabinowitz JD; Department of Chemistry/Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey., Li J; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Hou Z; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan., Dann CE 3rd; Department of Chemistry, Indiana University, Bloomington, Indiana. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu., Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu., Matherly LH; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2019 Oct; Vol. 18 (10), pp. 1787-1799. Date of Electronic Publication: 2019 Jul 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Dekhne+AS%22">Dekhne AS</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Shah+K%22">Shah K</searchLink>; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Ducker+GS%22">Ducker GS</searchLink>; Department of Chemistry/Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Katinas+JM%22">Katinas JM</searchLink>; Department of Chemistry, Indiana University, Bloomington, Indiana.<br /><searchLink fieldCode="AU" term="%22Wong-Roushar+J%22">Wong-Roushar J</searchLink>; Department of Chemistry, Indiana University, Bloomington, Indiana.<br /><searchLink fieldCode="AU" term="%22Nayeen+MJ%22">Nayeen MJ</searchLink>; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Doshi+A%22">Doshi A</searchLink>; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Ning+C%22">Ning C</searchLink>; Biochemistry and Molecular Biology, Jilin University, Changchun, Jilin Province, China.<br /><searchLink fieldCode="AU" term="%22Bao+X%22">Bao X</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Frühauf+J%22">Frühauf J</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Wallace-Povirk+A%22">Wallace-Povirk A</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22O'Connor+C%22">O'Connor C</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Dzinic+SH%22">Dzinic SH</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22White+K%22">White K</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Kushner+J%22">Kushner J</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Hüttemann+M%22">Hüttemann M</searchLink>; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Polin+L%22">Polin L</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Rabinowitz+JD%22">Rabinowitz JD</searchLink>; Department of Chemistry/Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Hou+Z%22">Hou Z</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Dann+CE+3rd%22">Dann CE 3rd</searchLink>; Department of Chemistry, Indiana University, Bloomington, Indiana. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu.<br /><searchLink fieldCode="AU" term="%22Gangjee+A%22">Gangjee A</searchLink>; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu.<br /><searchLink fieldCode="AU" term="%22Matherly+LH%22">Matherly LH</searchLink>; Department of Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan. matherly@karmanos.org gangjee@duq.edu cedann@indiana.edu.
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  Data: <searchLink fieldCode="JN" term="%22101132535%22">Molecular cancer therapeutics</searchLink> [Mol Cancer Ther] 2019 Oct; Vol. 18 (10), pp. 1787-1799. <i>Date of Electronic Publication: </i>2019 Jul 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%2C+Inc%22">American Association for Cancer Research, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101132535 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-8514 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215357163%22">15357163 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cancer Ther <i>Subsets: </i>MEDLINE
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