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Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.

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Title: Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Authors: Pegram LM; Department of Biochemistry, University of Colorado, Boulder, CO 80305., Liddle JC; Department of Biochemistry, University of Colorado, Boulder, CO 80305., Xiao Y; Department of Biochemistry, University of Colorado, Boulder, CO 80305., Hoh M; Department of Biochemistry, University of Colorado, Boulder, CO 80305., Rudolph J; Department of Biochemistry, University of Colorado, Boulder, CO 80305., Iverson DB; Department of Biochemistry, University of Colorado, Boulder, CO 80305., Vigers GP; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301., Smith D; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301., Zhang H; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301., Wang W; Structural Biology and Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080., Moffat JG; Structural Biology and Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080., Ahn NG; Department of Biochemistry, University of Colorado, Boulder, CO 80305; natalie.ahn@colorado.edu.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jul 30; Vol. 116 (31), pp. 15463-15468. Date of Electronic Publication: 2019 Jul 16.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
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  Data: <searchLink fieldCode="AU" term="%22Pegram+LM%22">Pegram LM</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80305.<br /><searchLink fieldCode="AU" term="%22Liddle+JC%22">Liddle JC</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80305.<br /><searchLink fieldCode="AU" term="%22Xiao+Y%22">Xiao Y</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80305.<br /><searchLink fieldCode="AU" term="%22Hoh+M%22">Hoh M</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80305.<br /><searchLink fieldCode="AU" term="%22Rudolph+J%22">Rudolph J</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80305.<br /><searchLink fieldCode="AU" term="%22Iverson+DB%22">Iverson DB</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80305.<br /><searchLink fieldCode="AU" term="%22Vigers+GP%22">Vigers GP</searchLink>; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301.<br /><searchLink fieldCode="AU" term="%22Smith+D%22">Smith D</searchLink>; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Structural Biology and Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080.<br /><searchLink fieldCode="AU" term="%22Moffat+JG%22">Moffat JG</searchLink>; Structural Biology and Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080.<br /><searchLink fieldCode="AU" term="%22Ahn+NG%22">Ahn NG</searchLink>; Department of Biochemistry, University of Colorado, Boulder, CO 80305; natalie.ahn@colorado.edu.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2019 Jul 30; Vol. 116 (31), pp. 15463-15468. <i>Date of Electronic Publication: </i>2019 Jul 16.
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