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Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.

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Title: Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.
Authors: Newell F; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Kong Y; Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing, 100142, China., Wilmott JS; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., Johansson PA; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Ferguson PM; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., Cui C; Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing, 100142, China., Li Z; Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing, 100142, China., Kazakoff SH; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Burke H; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., Dodds TJ; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., Patch AM; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Nones K; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Tembe V; Centre for Cancer Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, 2145, Australia., Shang P; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., van der Weyden L; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Wong K; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Holmes O; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Lo S; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., Leonard C; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Wood S; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Xu Q; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Rawson RV; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia., Mukhopadhyay P; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Dummer R; Dermatology Clinic, University Hospital Zürich, University of Zurich, Zurich, 8091, Switzerland., Levesque MP; Dermatology Clinic, University Hospital Zürich, University of Zurich, Zurich, 8091, Switzerland., Jönsson G; Department of Oncology, Clinical Sciences, Lund University, Lund, 221 85, Sweden., Wang X; Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing, 100142, China., Yeh I; Departments of Dermatology and Pathology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, 94143, USA., Wu H; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA., Joseph N; Department of Pathology, University of California, San Francisco, CA, 94143, USA., Bastian BC; Departments of Dermatology and Pathology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, 94143, USA., Long GV; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.; Royal North Shore and Mater Hospitals, Sydney, NSW, 2065, Australia., Spillane AJ; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., Shannon KF; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., Thompson JF; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.; Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia., Saw RPM; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia., Adams DJ; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK., Si L; Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing, 100142, China., Pearson JV; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Hayward NK; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Waddell N; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia., Mann GJ; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia.; Centre for Cancer Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, 2145, Australia., Guo J; Department of Renal Cancer and Melanoma, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing, 100142, China., Scolyer RA; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, 2065, Australia. richard.scolyer@melanoma.org.au.; Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia. richard.scolyer@melanoma.org.au.; Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia. richard.scolyer@melanoma.org.au.
Source: Nature communications [Nat Commun] 2019 Jul 18; Vol. 10 (1), pp. 3163. Date of Electronic Publication: 2019 Jul 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-019-11107-x