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Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer.

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Title: Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer.
Authors: Laheurte C; University Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000, Besançon, France.; INSERM CIC-1431, Clinical Investigation Center in Biotherapy, Plateforme de Biomonitoring, F-25000, Besançon, France., Dosset M; University Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000, Besançon, France., Vernerey D; University Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000, Besançon, France.; Department of medical Oncology, Methodology and Quality of Life Unit in Oncology, University Hospital of Besançon, F-25000, Besançon, France., Boullerot L; University Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000, Besançon, France.; INSERM CIC-1431, Clinical Investigation Center in Biotherapy, Plateforme de Biomonitoring, F-25000, Besançon, France., Gaugler B; UPMC Univ Paris 06, INSERM UMR 938, Centre de Recherche Saint-Antoine, Sorbonne Universités, F-75012, Paris, France., Gravelin E; University Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000, Besançon, France.; INSERM CIC-1431, Clinical Investigation Center in Biotherapy, Plateforme de Biomonitoring, F-25000, Besançon, France., Kaulek V; Department of Pneumology, University Hospital of Besançon, F-25000, Besançon, France., Jacquin M; INSERM CIC-1431, Clinical Investigation Center in Biotherapy, Plateforme de Biomonitoring, F-25000, Besançon, France., Cuche L; Department of Pneumology, University Hospital of Besançon, F-25000, Besançon, France., Eberst G; Department of Pneumology, University Hospital of Besançon, F-25000, Besançon, France., Jacoulet P; Department of Pneumology, University Hospital of Besançon, F-25000, Besançon, France., Fabre E; Department of medical Oncology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France., Le Pimpec-Barthes F; Department of Thoracic surgery, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France., Tartour E; Department of Biological Immuology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France., De Carvalho Bittencourt M; University Hospital of Nancy and CECITA team, IMOPA UMR7365 University of Lorraine/CNRS, Laboratory of Immunology, Vandoeuvre-les-Nancy, France., Westeel V; University Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000, Besançon, France.; Department of Pneumology, University Hospital of Besançon, F-25000, Besançon, France., Adotévi O; University Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000, Besançon, France. olivier.adotevi@univ-fcomte.fr.; INSERM CIC-1431, Clinical Investigation Center in Biotherapy, Plateforme de Biomonitoring, F-25000, Besançon, France. olivier.adotevi@univ-fcomte.fr.; Department of Pneumology, University Hospital of Besançon, F-25000, Besançon, France. olivier.adotevi@univ-fcomte.fr.
Source: British journal of cancer [Br J Cancer] 2019 Aug; Vol. 121 (5), pp. 405-416. Date of Electronic Publication: 2019 Jul 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-1827
DOI:10.1038/s41416-019-0531-5