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Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators.

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Title: Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators.
Authors: Conniot J; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Scomparin A; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Drug Science and Technology, University of Turin, Turin, Italy., Peres C; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Yeini E; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Pozzi S; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Matos AI; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Kleiner R; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Moura LIF; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Zupančič E; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Viana AS; Center of Chemistry and Biochemistry, Faculty of Sciences, Universidade de Lisboa, Lisbon, Portugal., Doron H; Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Gois PMP; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Erez N; Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Jung S; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Satchi-Fainaro R; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ronitsf@tauex.tau.ac.il., Florindo HF; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal. hflorindo@ff.ulisboa.pt.
Source: Nature nanotechnology [Nat Nanotechnol] 2019 Sep; Vol. 14 (9), pp. 891-901. Date of Electronic Publication: 2019 Aug 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101283273 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-3395 (Electronic) Linking ISSN: 17483387 NLM ISO Abbreviation: Nat Nanotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1748-3395
DOI:10.1038/s41565-019-0512-0