Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.

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Title: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Authors: Spangenberg E; Department of Neurobiology and Behavior, University of California Irvine (UCI), Irvine, CA, 92697, USA., Severson PL; Plexxikon Inc, Berkeley, CA, 94710, USA., Hohsfield LA; Department of Neurobiology and Behavior, University of California Irvine (UCI), Irvine, CA, 92697, USA., Crapser J; Department of Neurobiology and Behavior, University of California Irvine (UCI), Irvine, CA, 92697, USA., Zhang J; Plexxikon Inc, Berkeley, CA, 94710, USA., Burton EA; Plexxikon Inc, Berkeley, CA, 94710, USA., Zhang Y; Plexxikon Inc, Berkeley, CA, 94710, USA., Spevak W; Plexxikon Inc, Berkeley, CA, 94710, USA., Lin J; Plexxikon Inc, Berkeley, CA, 94710, USA., Phan NY; Department of Neurobiology and Behavior, University of California Irvine (UCI), Irvine, CA, 92697, USA., Habets G; Plexxikon Inc, Berkeley, CA, 94710, USA., Rymar A; Plexxikon Inc, Berkeley, CA, 94710, USA., Tsang G; Plexxikon Inc, Berkeley, CA, 94710, USA., Walters J; Plexxikon Inc, Berkeley, CA, 94710, USA., Nespi M; Plexxikon Inc, Berkeley, CA, 94710, USA., Singh P; Plexxikon Inc, Berkeley, CA, 94710, USA., Broome S; Plexxikon Inc, Berkeley, CA, 94710, USA., Ibrahim P; Plexxikon Inc, Berkeley, CA, 94710, USA., Zhang C; Plexxikon Inc, Berkeley, CA, 94710, USA., Bollag G; Plexxikon Inc, Berkeley, CA, 94710, USA., West BL; Plexxikon Inc, Berkeley, CA, 94710, USA., Green KN; Department of Neurobiology and Behavior, University of California Irvine (UCI), Irvine, CA, 92697, USA. kngreen@uci.edu.
Source: Nature communications [Nat Commun] 2019 Aug 21; Vol. 10 (1), pp. 3758. Date of Electronic Publication: 2019 Aug 21.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-019-11674-z