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Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization.

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Title: Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization.
Authors: Paul Friedman K; National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711., Gagne M; Healthy Environments and Consumer Safety Branch, Health Canada, Government of Canada, Ottawa, Ontario, Canada, K1A0K9., Loo LH; Innovations in Food and Chemical Safety Programme and Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore., Karamertzanis P; Computational Assessment Unit, European Chemicals Agency, European Chemicals Agency Annankatu 18, P.O. Box 400, FI-00121 Helsinki, Uusimaa, Finland., Netzeva T; Computational Assessment Unit, European Chemicals Agency, European Chemicals Agency Annankatu 18, P.O. Box 400, FI-00121 Helsinki, Uusimaa, Finland., Sobanski T; Computational Assessment Unit, European Chemicals Agency, European Chemicals Agency Annankatu 18, P.O. Box 400, FI-00121 Helsinki, Uusimaa, Finland., Franzosa JA; National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711., Richard AM; National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711., Lougee RR; National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711.; Oak Ridge Institute for Science and Education, U.S. Department of Energy, Oak Ridge, TN 37831, USA., Gissi A; Computational Assessment Unit, European Chemicals Agency, European Chemicals Agency Annankatu 18, P.O. Box 400, FI-00121 Helsinki, Uusimaa, Finland., Lee JJ; Innovations in Food and Chemical Safety Programme and Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore., Angrish M; National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC, 20004 and Research Triangle Park, NC 27711., Dorne JL; Scientific Committee and Emerging Risks Unit Department of Risk Assessment and Scientific Assistance, Via Carlo Magno 1A, 43126 Parma, Italy., Foster S; Office of Land and Emergency Management, U.S. Environmental Protection Agency, Washington, DC, 20004., Raffaele K; Office of Land and Emergency Management, U.S. Environmental Protection Agency, Washington, DC, 20004., Bahadori T; Oak Ridge Institute for Science and Education, U.S. Department of Energy, Oak Ridge, TN 37831, USA., Gwinn MR; National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711., Lambert J; National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711., Whelan M; European Commission, Joint Research Centre (JRC), Via Enrico Fermi, 2749, I - 21027 Ispra, Italy., Rasenberg M; Computational Assessment Unit, European Chemicals Agency, European Chemicals Agency Annankatu 18, P.O. Box 400, FI-00121 Helsinki, Uusimaa, Finland., Barton-Maclaren T; Healthy Environments and Consumer Safety Branch, Health Canada, Government of Canada, Ottawa, Ontario, Canada, K1A0K9., Thomas RS; National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711.
Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2020 Jan 01; Vol. 173 (1), pp. 202-225.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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