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Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population.

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Title: Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population.
Authors: Spring MD; Department of Bacterial and Parasitic Diseases, US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Silver Spring., Sousa JC; Experimental Therapeutics Branch, Silver Spring., Li Q; Experimental Therapeutics Branch, Silver Spring., Darko CA; General Dynamics Information Technology, Silver Spring., Morrison MN; Clinical Trials Center, Silver Spring., Marcsisin SR; Food and Drug Administration, Boston, Massachusetts., Mills KT; Davita Medical Group, Colorado Springs, Colorado., Potter BM; Experimental Therapeutics Branch, Silver Spring., Paolino KM; Division of Infectious Disease, SUNY Upstate Medical University, Syracuse, New York., Twomey PS; Licensing and Early Development-Oncology, Genentech, South San Francisco, California., Moon JE; Malaria Vaccine Branch, Silver Spring., Tosh DM; Clinical Operations, Government and Public Health Solutions, ICON, Hinckley, Ohio., Cicatelli SB; Clinical Trials Center, Silver Spring., Froude JW; Vaccines/Therapeutics Division, Defense Threat Reduction Agency, Fort Belvoir, Virginia., Pybus BS; Experimental Therapeutics Branch, Silver Spring., Oliver TG; Clinical Pharamacology Division, Silver Spring., McCarthy WF; U. S. Army Medical Materiel Development Activity, Fort Detrick, Maryland., Waters NC; Department of Bacterial and Parasitic Diseases, US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Smith PL; Center for Enabling Capabilities, Silver Spring., Reichard GA; Experimental Therapeutics Branch, Silver Spring., Bennett JW; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Silver Spring.; Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring.
Source: The Journal of infectious diseases [J Infect Dis] 2019 Oct 22; Vol. 220 (11), pp. 1761-1770.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population.
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  Data: <searchLink fieldCode="AU" term="%22Spring+MD%22">Spring MD</searchLink>; Department of Bacterial and Parasitic Diseases, US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Sousa+JC%22">Sousa JC</searchLink>; Experimental Therapeutics Branch, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Experimental Therapeutics Branch, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Darko+CA%22">Darko CA</searchLink>; General Dynamics Information Technology, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Morrison+MN%22">Morrison MN</searchLink>; Clinical Trials Center, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Marcsisin+SR%22">Marcsisin SR</searchLink>; Food and Drug Administration, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mills+KT%22">Mills KT</searchLink>; Davita Medical Group, Colorado Springs, Colorado.<br /><searchLink fieldCode="AU" term="%22Potter+BM%22">Potter BM</searchLink>; Experimental Therapeutics Branch, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Paolino+KM%22">Paolino KM</searchLink>; Division of Infectious Disease, SUNY Upstate Medical University, Syracuse, New York.<br /><searchLink fieldCode="AU" term="%22Twomey+PS%22">Twomey PS</searchLink>; Licensing and Early Development-Oncology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Moon+JE%22">Moon JE</searchLink>; Malaria Vaccine Branch, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Tosh+DM%22">Tosh DM</searchLink>; Clinical Operations, Government and Public Health Solutions, ICON, Hinckley, Ohio.<br /><searchLink fieldCode="AU" term="%22Cicatelli+SB%22">Cicatelli SB</searchLink>; Clinical Trials Center, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Froude+JW%22">Froude JW</searchLink>; Vaccines/Therapeutics Division, Defense Threat Reduction Agency, Fort Belvoir, Virginia.<br /><searchLink fieldCode="AU" term="%22Pybus+BS%22">Pybus BS</searchLink>; Experimental Therapeutics Branch, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Oliver+TG%22">Oliver TG</searchLink>; Clinical Pharamacology Division, Silver Spring.<br /><searchLink fieldCode="AU" term="%22McCarthy+WF%22">McCarthy WF</searchLink>; U. S. Army Medical Materiel Development Activity, Fort Detrick, Maryland.<br /><searchLink fieldCode="AU" term="%22Waters+NC%22">Waters NC</searchLink>; Department of Bacterial and Parasitic Diseases, US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Smith+PL%22">Smith PL</searchLink>; Center for Enabling Capabilities, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Reichard+GA%22">Reichard GA</searchLink>; Experimental Therapeutics Branch, Silver Spring.<br /><searchLink fieldCode="AU" term="%22Bennett+JW%22">Bennett JW</searchLink>; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Silver Spring.; Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring.
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  Data: <searchLink fieldCode="JN" term="%220413675%22">The Journal of infectious diseases</searchLink> [J Infect Dis] 2019 Oct 22; Vol. 220 (11), pp. 1761-1770.
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