Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia.

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Title: Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia.
Authors: Favié LMA; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. l.m.a.favie@umcutrecht.nl.; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. l.m.a.favie@umcutrecht.nl., Peeters-Scholte CMPCD; Neurophyxia B.V., 's-Hertogenbosch, the Netherlands., Bakker A; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., Tjabbes H; Neurophyxia B.V., 's-Hertogenbosch, the Netherlands., Egberts TCG; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Department of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, the Netherlands., van Bel F; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Rademaker CMA; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., Vis P; LAP&P Consultants BV, Leiden, the Netherlands., Groenendaal F; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Source: Pediatric research [Pediatr Res] 2020 Mar; Vol. 87 (4), pp. 689-696. Date of Electronic Publication: 2019 Oct 02.
Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1530-0447
DOI:10.1038/s41390-019-0587-1