Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.

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Title: Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.
Authors: Findlay AD; Pharmaxis Ltd , 20 Rodborough Road, Frenchs Forest , Sydney , New South Wales 2086 , Australia., Foot JS; Pharmaxis Ltd , 20 Rodborough Road, Frenchs Forest , Sydney , New South Wales 2086 , Australia., Buson A; Pharmaxis Ltd , 20 Rodborough Road, Frenchs Forest , Sydney , New South Wales 2086 , Australia., Deodhar M; Pharmaxis Ltd , 20 Rodborough Road, Frenchs Forest , Sydney , New South Wales 2086 , Australia., Jarnicki AG; Centre for Healthy Lungs , The University of Newcastle and Hunter Medical Research Institute , Newcastle , New South Wales 2300 , Australia., Hansbro PM; Centre for Healthy Lungs , The University of Newcastle and Hunter Medical Research Institute , Newcastle , New South Wales 2300 , Australia.; Centre for Inflammation , Centenary Institute , Sydney , New South Wales 2050 , Australia.; Faculty of Science , University of Technology Sydney , Ultimo , New South Wales 2007 , Australia., Liu G; Centre for Inflammation , Centenary Institute , Sydney , New South Wales 2050 , Australia.; Faculty of Science , University of Technology Sydney , Ultimo , New South Wales 2007 , Australia., Schilter H; Pharmaxis Ltd , 20 Rodborough Road, Frenchs Forest , Sydney , New South Wales 2086 , Australia., Turner CI; Pharmaxis Ltd , 20 Rodborough Road, Frenchs Forest , Sydney , New South Wales 2086 , Australia., Zhou W; Pharmaxis Ltd , 20 Rodborough Road, Frenchs Forest , Sydney , New South Wales 2086 , Australia., Jarolimek W; Pharmaxis Ltd , 20 Rodborough Road, Frenchs Forest , Sydney , New South Wales 2086 , Australia.
Source: Journal of medicinal chemistry [J Med Chem] 2019 Nov 14; Vol. 62 (21), pp. 9874-9889. Date of Electronic Publication: 2019 Oct 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.9b01283