Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.
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| Title: | Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations. |
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| Authors: | Taskar KS; GlaxoSmithKline, DMPK, In Vitro In Vivo Translation, GSK R&D, Ware, UK., Pilla Reddy V; AstraZeneca, Modelling and Simulation, Early Oncology DMPK, Oncology R&D, AstraZeneca, Cambridge, UK., Burt H; Simcyp-Division, Certara UK Ltd., Sheffield, UK., Posada MM; Eli Lilly & Company, Indianapolis, Indiana, USA., Varma M; Pfizer Inc., Groton, Connecticut, USA., Zheng M; Bristol-Myers Squibb Company, Princeton, New Jersey, USA., Ullah M; Roche Innovation Center, Basel, Switzerland., Emami Riedmaier A; AbbVie Inc., North Chicago, Illinois, USA., Umehara KI; Roche Innovation Center, Basel, Switzerland., Snoeys J; Janssen Research and Development, Beerse, Belgium., Nakakariya M; Takeda Pharmaceutical Company Ltd., Kanagawa, Japan., Chu X; Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA., Beneton M; Servier, Centre-Val de Loire, France., Chen Y; Genentech, San Francisco, California, USA., Huth F; Novartis, Basel, Switzerland., Narayanan R; Shire, Lexington, Massachusetts, USA., Mukherjee D; AbbVie Inc., North Chicago, Illinois, USA., Dixit V; Eisai Inc., Woodliff Lake, New Jersey, USA., Sugiyama Y; Sugiyama Laboratory, Riken, Yokohama, Japan., Neuhoff S; Simcyp-Division, Certara UK Ltd., Sheffield, UK. |
| Source: | Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 May; Vol. 107 (5), pp. 1082-1115. Date of Electronic Publication: 2019 Dec 31. |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1532-6535 |
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| DOI: | 10.1002/cpt.1693 |
