KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.

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Title: KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.
Authors: Spiombi E; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, 20090, Segrate, Milan, Italy., Angrisani A; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Fonte S; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., De Feudis G; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Department of Experimental Oncology, European Institute of Oncology, 20139, Milan, Italy., Fabretti F; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Cucchi D; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Barts Cancer Institute, Queen Mary University of London, Centre for Molecular Oncology, John Vane Science Center, London, EC1M 6BQ, UK., Izzo M; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy., Infante P; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy., Miele E; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Department of Hematology/Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy., Po A; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Di Magno L; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy., Magliozzi R; Kymab ltd, Babraham Campus, Cambridge, CB22 3AT, UK., Guardavaccaro D; Department of Biotechnology, University of Verona, Verona, Italy., Maroder M; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Canettieri G; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161, Rome, Italy., Giannini G; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161, Rome, Italy., Ferretti E; Department of Experimental Medicine, Sapienza University, 00161, Rome, Italy., Gulino A; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy., Di Marcotullio L; Department of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161, Rome, Italy., Moretti M; Department of Experimental Medicine, Sapienza University, 00161, Rome, Italy., De Smaele E; Department of Experimental Medicine, Sapienza University, 00161, Rome, Italy. enrico.desmaele@uniroma1.it.
Source: Oncogenesis [Oncogenesis] 2019 Nov 04; Vol. 8 (11), pp. 64. Date of Electronic Publication: 2019 Nov 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101580004 Publication Model: Electronic Cited Medium: Print ISSN: 2157-9024 (Print) Linking ISSN: 21579024 NLM ISO Abbreviation: Oncogenesis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2157-9024
DOI:10.1038/s41389-019-0175-6