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Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization.

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Title: Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization.
Authors: Fowlkes JL; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States. Electronic address: fowlkesjohnl@uky.edu., Bunn RC; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States., Ray PD; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States., Kalaitzoglou E; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States., Uppuganti S; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States., Unal M; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States., Nyman JS; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, United States., Thrailkill KM; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States.
Source: Bone [Bone] 2020 Jan; Vol. 130, pp. 115106. Date of Electronic Publication: 2019 Nov 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization.
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  Data: <searchLink fieldCode="AU" term="%22Fowlkes+JL%22">Fowlkes JL</searchLink>; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States. Electronic address: fowlkesjohnl@uky.edu.<br /><searchLink fieldCode="AU" term="%22Bunn+RC%22">Bunn RC</searchLink>; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States.<br /><searchLink fieldCode="AU" term="%22Ray+PD%22">Ray PD</searchLink>; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States.<br /><searchLink fieldCode="AU" term="%22Kalaitzoglou+E%22">Kalaitzoglou E</searchLink>; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States.<br /><searchLink fieldCode="AU" term="%22Uppuganti+S%22">Uppuganti S</searchLink>; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States.<br /><searchLink fieldCode="AU" term="%22Unal+M%22">Unal M</searchLink>; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States.<br /><searchLink fieldCode="AU" term="%22Nyman+JS%22">Nyman JS</searchLink>; Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37232, United States; Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, United States.<br /><searchLink fieldCode="AU" term="%22Thrailkill+KM%22">Thrailkill KM</searchLink>; University of Kentucky Barnstable Brown Diabetes Center, Lexington, KY, 40536, United States; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, 40536, United States.
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  Data: <searchLink fieldCode="JN" term="%228504048%22">Bone</searchLink> [Bone] 2020 Jan; Vol. 130, pp. 115106. <i>Date of Electronic Publication: </i>2019 Nov 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8504048 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2763 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218732763%22">18732763 </searchLink><i>NLM ISO Abbreviation: </i>Bone <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bone.2019.115106
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        Text: English
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              Text: 2020 Jan
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