A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
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| Title: | A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. |
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| Authors: | Arnold ND; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Pickworth JA; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., West LE; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Dawson S; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Carvalho JA; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK., Casbolt H; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Braithwaite AT; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Iremonger J; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Renshall L; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Germaschewski V; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK., McCourt M; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK., Bland-Ward P; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK., Kowash H; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Hameed AG; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Rothman AMK; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Frid MG; Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Roger Thompson AA; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Evans HR; Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK., Southwood M; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospital, Cambridge, CB2 0QQ, UK., Morrell NW; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospital, Cambridge, CB2 0QQ, UK., Crossman DC; School of Medicine, University of St. Andrews, St, Andrews, KY16 9AJ, UK., Whyte MKB; MRC/University of Edinburgh Centre for Inflammation Research, University of Edinburgh, The Queens Medical Research Institute, Edinburgh, EH16 4TJ, UK., Stenmark KR; Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Newman CM; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Kiely DG; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.; Sheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals Foundation Trust, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK., Francis SE; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Lawrie A; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK. a.lawrie@sheffield.ac.uk. |
| Source: | Nature communications [Nat Commun] 2019 Nov 15; Vol. 10 (1), pp. 5183. Date of Electronic Publication: 2019 Nov 15. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-019-13139-9 |
