Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
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| Title: | Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation. |
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| Authors: | Bai C; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Reid EE; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Wilhelm A; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Shizuka M; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Maloney EK; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Laleau R; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Harvey L; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Archer KE; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Vitharana D; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Adams S; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Kovtun Y; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Miller ML; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Chari R; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Keating TA; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Yoder NC; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States. |
| Source: | Bioconjugate chemistry [Bioconjug Chem] 2020 Jan 15; Vol. 31 (1), pp. 93-103. Date of Electronic Publication: 2019 Dec 10. |
| Publication Type: | Comparative Study; Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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