Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.
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| Title: | Strong T |
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| Authors: | Chamcha V; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Reddy PBJ; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Kannanganat S; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Wilkins C; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Gangadhara S; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Velu V; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Green R; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Law GL; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Chang J; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Bowen JR; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Kozlowski PA; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Lifton M; Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Santra S; Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Legere T; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Chea LS; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Chennareddi L; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Yu T; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA., Suthar MS; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Silvestri G; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Derdeyn CA; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Gale M Jr; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Villinger F; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Hunter E; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Amara RR; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. ramara@emory.edu.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2019 Nov 20; Vol. 11 (519). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aav1800 |
