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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

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Title: Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Authors: Weaver RJ; Biopharmacy, Institute de Recherches Internationales Servier, Suresnes, France. richard.weaver@servier.com., Blomme EA; Global Preclinical Safety, Abbvie, North Chicago, IL, USA., Chadwick AE; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK., Copple IM; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK., Gerets HHJ; Development Science, UCB BioPharma SPRL, Braine-l'Alleud, Belgium., Goldring CE; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK., Guillouzo A; INSERM, INRA, Institut NUMECAN (Nutrition Metabolisms and Cancer), UMR_S 1241, University Rennes, Rennes, France., Hewitt PG; Chemical and Preclinical Safety, Merck Healthcare KGaA, Darmstadt, Germany., Ingelman-Sundberg M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Jensen KG; Drug ADME Research, H. Lundbeck A/S, Valby, Denmark., Juhila S; In Vitro Biology, Orion Pharma, Espoo, Finland., Klingmüller U; Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany., Labbe G; Investigative Toxicology, Preclinical Safety, Sanofi R&D, Paris, France., Liguori MJ; Global Preclinical Safety, Abbvie, North Chicago, IL, USA., Lovatt CA; Non-Clinical Safety, GlaxoSmithKline, Ware, UK., Morgan P; Clinical Pharmacology and Safety Sciences, Biopharmaceuticals Science Unit, AstraZeneca, Cambridge, UK., Naisbitt DJ; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK., Pieters RHH; Immunotoxicology, Faculty of Veterinary Medicines, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands., Snoeys J; Drug Metabolism and Pharmacokinetics, Janssen Research and Development, Beerse, Belgium., van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands., Williams DP; Clinical Pharmacology and Safety Sciences, Biopharmaceuticals Science Unit, AstraZeneca, Cambridge, UK., Park BK; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK. bkpark@liverpool.ac.uk.
Source: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2020 Feb; Vol. 19 (2), pp. 131-148. Date of Electronic Publication: 2019 Nov 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-1784
DOI:10.1038/s41573-019-0048-x