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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

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Title: Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Authors: Weaver RJ; Biopharmacy, Institute de Recherches Internationales Servier, Suresnes, France. richard.weaver@servier.com., Blomme EA; Global Preclinical Safety, Abbvie, North Chicago, IL, USA., Chadwick AE; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK., Copple IM; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK., Gerets HHJ; Development Science, UCB BioPharma SPRL, Braine-l'Alleud, Belgium., Goldring CE; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK., Guillouzo A; INSERM, INRA, Institut NUMECAN (Nutrition Metabolisms and Cancer), UMR_S 1241, University Rennes, Rennes, France., Hewitt PG; Chemical and Preclinical Safety, Merck Healthcare KGaA, Darmstadt, Germany., Ingelman-Sundberg M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Jensen KG; Drug ADME Research, H. Lundbeck A/S, Valby, Denmark., Juhila S; In Vitro Biology, Orion Pharma, Espoo, Finland., Klingmüller U; Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany., Labbe G; Investigative Toxicology, Preclinical Safety, Sanofi R&D, Paris, France., Liguori MJ; Global Preclinical Safety, Abbvie, North Chicago, IL, USA., Lovatt CA; Non-Clinical Safety, GlaxoSmithKline, Ware, UK., Morgan P; Clinical Pharmacology and Safety Sciences, Biopharmaceuticals Science Unit, AstraZeneca, Cambridge, UK., Naisbitt DJ; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK., Pieters RHH; Immunotoxicology, Faculty of Veterinary Medicines, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands., Snoeys J; Drug Metabolism and Pharmacokinetics, Janssen Research and Development, Beerse, Belgium., van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands., Williams DP; Clinical Pharmacology and Safety Sciences, Biopharmaceuticals Science Unit, AstraZeneca, Cambridge, UK., Park BK; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK. bkpark@liverpool.ac.uk.
Source: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2020 Feb; Vol. 19 (2), pp. 131-148. Date of Electronic Publication: 2019 Nov 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Weaver+RJ%22">Weaver RJ</searchLink>; Biopharmacy, Institute de Recherches Internationales Servier, Suresnes, France. richard.weaver@servier.com.<br /><searchLink fieldCode="AU" term="%22Blomme+EA%22">Blomme EA</searchLink>; Global Preclinical Safety, Abbvie, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chadwick+AE%22">Chadwick AE</searchLink>; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Copple+IM%22">Copple IM</searchLink>; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Gerets+HHJ%22">Gerets HHJ</searchLink>; Development Science, UCB BioPharma SPRL, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Goldring+CE%22">Goldring CE</searchLink>; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Guillouzo+A%22">Guillouzo A</searchLink>; INSERM, INRA, Institut NUMECAN (Nutrition Metabolisms and Cancer), UMR_S 1241, University Rennes, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Hewitt+PG%22">Hewitt PG</searchLink>; Chemical and Preclinical Safety, Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Ingelman-Sundberg+M%22">Ingelman-Sundberg M</searchLink>; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Jensen+KG%22">Jensen KG</searchLink>; Drug ADME Research, H. Lundbeck A/S, Valby, Denmark.<br /><searchLink fieldCode="AU" term="%22Juhila+S%22">Juhila S</searchLink>; In Vitro Biology, Orion Pharma, Espoo, Finland.<br /><searchLink fieldCode="AU" term="%22Klingmüller+U%22">Klingmüller U</searchLink>; Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Labbe+G%22">Labbe G</searchLink>; Investigative Toxicology, Preclinical Safety, Sanofi R&D, Paris, France.<br /><searchLink fieldCode="AU" term="%22Liguori+MJ%22">Liguori MJ</searchLink>; Global Preclinical Safety, Abbvie, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Lovatt+CA%22">Lovatt CA</searchLink>; Non-Clinical Safety, GlaxoSmithKline, Ware, UK.<br /><searchLink fieldCode="AU" term="%22Morgan+P%22">Morgan P</searchLink>; Clinical Pharmacology and Safety Sciences, Biopharmaceuticals Science Unit, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Naisbitt+DJ%22">Naisbitt DJ</searchLink>; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Pieters+RHH%22">Pieters RHH</searchLink>; Immunotoxicology, Faculty of Veterinary Medicines, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Snoeys+J%22">Snoeys J</searchLink>; Drug Metabolism and Pharmacokinetics, Janssen Research and Development, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22van+de+Water+B%22">van de Water B</searchLink>; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Williams+DP%22">Williams DP</searchLink>; Clinical Pharmacology and Safety Sciences, Biopharmaceuticals Science Unit, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Park+BK%22">Park BK</searchLink>; Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK. bkpark@liverpool.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101124171%22">Nature reviews. Drug discovery</searchLink> [Nat Rev Drug Discov] 2020 Feb; Vol. 19 (2), pp. 131-148. <i>Date of Electronic Publication: </i>2019 Nov 20.
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