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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity.

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Title: Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity.
Authors: Angiari S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address: angiaris@tcd.ie., Runtsch MC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Sutton CE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Palsson-McDermott EM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Kelly B; Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany., Rana N; Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany., Kane H; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., Papadopoulou G; Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens 115 27, Athens, Greece., Pearce EL; Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany., Mills KHG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address: laoneill@tcd.ie.
Source: Cell metabolism [Cell Metab] 2020 Feb 04; Vol. 31 (2), pp. 391-405.e8. Date of Electronic Publication: 2019 Nov 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4<superscript>+</superscript> T Cell Pathogenicity and Suppresses Autoimmunity.
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  Data: <searchLink fieldCode="AU" term="%22Angiari+S%22">Angiari S</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address: angiaris@tcd.ie.<br /><searchLink fieldCode="AU" term="%22Runtsch+MC%22">Runtsch MC</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland.<br /><searchLink fieldCode="AU" term="%22Sutton+CE%22">Sutton CE</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland.<br /><searchLink fieldCode="AU" term="%22Palsson-McDermott+EM%22">Palsson-McDermott EM</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland.<br /><searchLink fieldCode="AU" term="%22Kelly+B%22">Kelly B</searchLink>; Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rana+N%22">Rana N</searchLink>; Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kane+H%22">Kane H</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland.<br /><searchLink fieldCode="AU" term="%22Papadopoulou+G%22">Papadopoulou G</searchLink>; Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens 115 27, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Pearce+EL%22">Pearce EL</searchLink>; Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mills+KHG%22">Mills KHG</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland.<br /><searchLink fieldCode="AU" term="%22O'Neill+LAJ%22">O'Neill LAJ</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address: laoneill@tcd.ie.
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  Data: <searchLink fieldCode="JN" term="%22101233170%22">Cell metabolism</searchLink> [Cell Metab] 2020 Feb 04; Vol. 31 (2), pp. 391-405.e8. <i>Date of Electronic Publication: </i>2019 Nov 21.
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        Value: 10.1016/j.cmet.2019.10.015
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