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The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.

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Title: The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
Authors: Goldberg FW; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Finlay MRV; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Ting AKT; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Beattie D; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Lamont GM; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Fallan C; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Wrigley GL; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Schimpl M; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Howard MR; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Williamson B; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Vazquez-Chantada M; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Barratt DG; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Davies BR; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Cadogan EB; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Ramos-Montoya A; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K., Dean E; Oncology R&D, AstraZeneca, Cambridge CB4 0FZ, U.K.
Source: Journal of medicinal chemistry [J Med Chem] 2020 Apr 09; Vol. 63 (7), pp. 3461-3471. Date of Electronic Publication: 2020 Jan 15.
Publication Type: News
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.9b01684