Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation.

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Title: Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation.
Authors: Steen-Louws C; Center for Translational Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands., Boross P; Center for Translational Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands., Prado J; Center for Translational Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands., Meeldijk J; Center for Translational Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands., Langenhorst JB; Center for Translational Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands., Huitema ADR; Department of Clinical Pharmacy, UMC Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, Netherlands., den Hartog MT; Bioceros Holding B.V., Utrecht, Netherlands., Boon L; Bioceros Holding B.V., Utrecht, Netherlands., Lafeber FPJG; Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands., Hack CE; Center for Translational Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands., Eijkelkamp N; Center for Translational Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands., Popov-Celeketic J; Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht University, Utrecht, Netherlands. J.Popov-Celeketic@umcutrecht.nl.
Source: Pharmaceutical research [Pharm Res] 2019 Dec 26; Vol. 37 (2), pp. 17. Date of Electronic Publication: 2019 Dec 26.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-904X
DOI:10.1007/s11095-019-2744-y