Fibrinogen αC-regions are not directly involved in fibrin polymerization as evidenced by a "Double-Detroit" recombinant fibrinogen mutant and knobs-mimic peptides.

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Title: Fibrinogen αC-regions are not directly involved in fibrin polymerization as evidenced by a "Double-Detroit" recombinant fibrinogen mutant and knobs-mimic peptides.
Authors: Duval C; Leeds Thrombosis Collective, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Profumo A; Biopolimeri e Proteomica, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Aprile A; Biopolimeri e Proteomica, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Salis A; Department of Experimental Medicine, Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy., Millo E; Department of Experimental Medicine, Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy., Damonte G; Department of Experimental Medicine, Center of Excellence for Biomedical Research (CEBR), University of Genova, Genova, Italy., Gauer JS; Leeds Thrombosis Collective, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Ariëns RAS; Leeds Thrombosis Collective, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Rocco M; Biopolimeri e Proteomica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Apr; Vol. 18 (4), pp. 802-814. Date of Electronic Publication: 2020 Jan 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7836
DOI:10.1111/jth.14725