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In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors.

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Title: In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors.
Authors: Nass K; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.; Paul Scherrer Institute (PSI), Forschungstrasse 111, 5232, Villigen, PSI, Switzerland., Redecke L; Joint Laboratory for Structural Biology of Infection and Inflammation, Institute of Biochemistry and Molecular Biology, University of Hamburg, and Institute of Biochemistry, University of Lübeck, at Deutsches Elektronen-Synchrotron (DESY), Notkestr. 85, 22607, Hamburg, Germany.; German Centre for Infection Research, University of Lübeck, 23562, Lübeck, Germany.; Institute of Biochemistry, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.; Deutsches Elektronen Synchrotron (DESY), Photon Science, Notkestr. 85, 22607, Hamburg, Germany., Perbandt M; Institute of Biochemistry and Molecular Biology, University of Hamburg, at Deutsches Elektronen-Synchrotron (DESY), Notkestr. 85, 22607, Hamburg, Germany.; The Hamburg Centre for Ultrafast Imaging (CUI), Luruper Chaussee 149, 22761, Hamburg, Germany., Yefanov O; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany., Klinge M; Joint Laboratory for Structural Biology of Infection and Inflammation, Institute of Biochemistry and Molecular Biology, University of Hamburg, and Institute of Biochemistry, University of Lübeck, at Deutsches Elektronen-Synchrotron (DESY), Notkestr. 85, 22607, Hamburg, Germany.; BioAgilytix Europe GmbH, Lademannbogen 10, 22339, Hamburg, Germany., Koopmann R; Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str.4, 72076, Tübingen, Germany., Stellato F; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.; Dipartimento di Fisica, Università di Roma Tor Vergata and INFN, Via della Ricerca Scientifica 1, 00133, Rome, Italy., Gabdulkhakov A; Institute of Protein Research, Russian Academy of Sciences, 4 Institutskaya Str., Pushchino, Moscow Region, Russia, 142290., Schönherr R; Institute of Biochemistry, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.; Deutsches Elektronen Synchrotron (DESY), Photon Science, Notkestr. 85, 22607, Hamburg, Germany., Rehders D; Joint Laboratory for Structural Biology of Infection and Inflammation, Institute of Biochemistry and Molecular Biology, University of Hamburg, and Institute of Biochemistry, University of Lübeck, at Deutsches Elektronen-Synchrotron (DESY), Notkestr. 85, 22607, Hamburg, Germany.; BODE Chemie GmbH, Melanchthonstraße 27, 22525, Hamburg, Germany., Lahey-Rudolph JM; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.; Institute of Biochemistry, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Aquila A; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.; LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA, 94025, USA., Barty A; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany., Basu S; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, 85287-160, USA.; European Molecular Biology Laboratory (EMBL), Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, Grenoble, France., Doak RB; Department of Physics, Arizona State University, Tempe, AZ, 85411, USA.; Max Planck Institute for Medical Research, Jahnstr. 29, 69120, Heidelberg, Germany., Duden R; Institute of Biology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Frank M; Biology and Biotechnology Division, Physical & Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, 94550, USA., Fromme R; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, 85287-160, USA., Kassemeyer S; Max-Planck-Institute for Medical Research, Jahnstr. 29, 69120, Heidelberg, Germany., Katona G; Department of Chemistry and Molecular Biology, University of Gothenburg, 40530, Gothenburg, Sweden., Kirian R; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, 85287-160, USA., Liu H; Department of Physics, Arizona State University, Tempe, AZ, 85411, USA.; Complex Systems Division, Beijing Computational Science Research Center, 100193, Beijing, China., Majoul I; Institute of Biology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Martin-Garcia JM; Center for Applied Structural Discovery (CASD), Biodesign Institute, Arizona State University, 727 East Tyler Street, Tempe, AZ, 85287, USA., Messerschmidt M; LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA, 94025, USA.; Center for Applied Structural Discovery (CASD), Biodesign Institute, Arizona State University, 727 East Tyler Street, Tempe, AZ, 85287, USA., Shoeman RL; Max-Planck-Institute for Medical Research, Jahnstr. 29, 69120, Heidelberg, Germany., Weierstall U; Department of Physics, Arizona State University, Tempe, AZ, 85411, USA., Westenhoff S; Department of Chemistry and Molecular Biology, University of Gothenburg, 40530, Gothenburg, Sweden., White TA; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany., Williams GJ; LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA, 94025, USA.; Brookhaven National Laboratory (BNL), PO Box 5000, Upton, NY, 11973-5000, USA., Yoon CH; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.; LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA, 94025, USA., Zatsepin N; Department of Physics, Arizona State University, Tempe, AZ, 85411, USA.; ARC Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Victoria, 3086, Australia., Fromme P; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, 85287-160, USA., Duszenko M; Institute of Neurophysiology, University of Tübingen, Keplerstr. 15, 72074, Tübingen, Germany., Chapman HN; Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.; The Hamburg Centre for Ultrafast Imaging (CUI), Luruper Chaussee 149, 22761, Hamburg, Germany.; Department of Physics, University of Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany., Betzel C; Institute of Biochemistry and Molecular Biology, University of Hamburg, at Deutsches Elektronen-Synchrotron (DESY), Notkestr. 85, 22607, Hamburg, Germany. christian.betzel@uni-hamburg.de.; The Hamburg Centre for Ultrafast Imaging (CUI), Luruper Chaussee 149, 22761, Hamburg, Germany. christian.betzel@uni-hamburg.de.
Source: Nature communications [Nat Commun] 2020 Jan 30; Vol. 11 (1), pp. 620. Date of Electronic Publication: 2020 Jan 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-020-14484-w