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Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.

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Title: Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.
Authors: Sharma M; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khong H; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fa'ak F; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bentebibel SE; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Janssen LME; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chesson BC; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Creasy CA; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Forget MA; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kahn LMS; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pazdrak B; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Karki B; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hailemichael Y; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Singh M; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vianden C; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vennam S; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA., Bharadwaj U; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Tweardy DJ; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Haymaker C; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bernatchez C; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Huang S; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Houston, TX, USA., Rajapakshe K; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Hurwitz ME; Yale Comprehensive Cancer Center, New Haven, CT, USA., Sznol M; Yale University Cancer Center, Yale University, New Haven, CT, USA., Hwu P; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hoch U; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA., Addepalli M; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA., Charych DH; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA., Zalevsky J; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA., Diab A; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Overwijk WW; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. woverwijk@nektar.com.; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA. woverwijk@nektar.com.; The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA. woverwijk@nektar.com.; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. woverwijk@nektar.com.
Source: Nature communications [Nat Commun] 2020 Jan 31; Vol. 11 (1), pp. 661. Date of Electronic Publication: 2020 Jan 31.
Publication Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.
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  Data: <searchLink fieldCode="AU" term="%22Sharma+M%22">Sharma M</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Khong+H%22">Khong H</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Fa'ak+F%22">Fa'ak F</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bentebibel+SE%22">Bentebibel SE</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Janssen+LME%22">Janssen LME</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chesson+BC%22">Chesson BC</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Creasy+CA%22">Creasy CA</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Forget+MA%22">Forget MA</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kahn+LMS%22">Kahn LMS</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Pazdrak+B%22">Pazdrak B</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Karki+B%22">Karki B</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hailemichael+Y%22">Hailemichael Y</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Singh+M%22">Singh M</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vianden+C%22">Vianden C</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vennam+S%22">Vennam S</searchLink>; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bharadwaj+U%22">Bharadwaj U</searchLink>; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Tweardy+DJ%22">Tweardy DJ</searchLink>; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Haymaker+C%22">Haymaker C</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bernatchez+C%22">Bernatchez C</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Rajapakshe+K%22">Rajapakshe K</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Coarfa+C%22">Coarfa C</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hurwitz+ME%22">Hurwitz ME</searchLink>; Yale Comprehensive Cancer Center, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Sznol+M%22">Sznol M</searchLink>; Yale University Cancer Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hwu+P%22">Hwu P</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hoch+U%22">Hoch U</searchLink>; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Addepalli+M%22">Addepalli M</searchLink>; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Charych+DH%22">Charych DH</searchLink>; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zalevsky+J%22">Zalevsky J</searchLink>; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Diab+A%22">Diab A</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Overwijk+WW%22">Overwijk WW</searchLink>; Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. woverwijk@nektar.com.; Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, USA. woverwijk@nektar.com.; The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA. woverwijk@nektar.com.; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. woverwijk@nektar.com.
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