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A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7.

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Title: A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7.
Authors: Yu C; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Wang L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115., Rowe RG; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115.; Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115., Han A; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115.; Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115., Ji W; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., McMahon C; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Baier AS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Huang YC; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115.; Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115., Marion W; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115.; Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115., Pearson DS; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115.; Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Daley GQ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115.; Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115., Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; hao.wu@childrens.harvard.edu piotr.sliz@childrens.harvard.edu.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115., Sliz P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; hao.wu@childrens.harvard.edu piotr.sliz@childrens.harvard.edu.; Computational Health Informatics Program, Boston Children's Hospital, Boston, MA 02115.; Molecular Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 03; Vol. 117 (9), pp. 4653-4663. Date of Electronic Publication: 2020 Feb 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.1919409117