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Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial.

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Title: Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial.
Authors: Howard JF Jr; University of North Carolina, Chapel Hill., Nowak RJ; Yale School of Medicine, New Haven, Connecticut., Wolfe GI; University at Buffalo, Buffalo, New York., Freimer ML; Ohio State University, Columbus., Vu TH; University of South Florida, Tampa., Hinton JL; Infirmary Health, Mobile, Alabama., Benatar M; University of Miami, Miami, Florida., Duda PW; Ra Pharmaceuticals Inc, Cambridge, Massachusetts., MacDougall JE; Ra Pharmaceuticals Inc, Cambridge, Massachusetts., Farzaneh-Far R; Ra Pharmaceuticals Inc, Cambridge, Massachusetts., Kaminski HJ; George Washington University, Washington, DC., Barohn R; University of Kansas, Fairway., Dimachkie M; University of Kansas, Fairway., Pasnoor M; University of Kansas, Fairway., Farmakidis C; University of Kansas, Fairway., Liu T; University of Kansas, Fairway., Colgan S; University of Kansas, Fairway., Benatar MG; University of Miami, Miami, Florida., Bertorini T; Wesley Neurology Clinic, Cordova, Tennessee., Pillai R; Wesley Neurology Clinic, Cordova, Tennessee., Henegar R; Wesley Neurology Clinic, Cordova, Tennessee., Bromberg M; University of Utah, Salt Lake City., Gibson S; University of Utah, Salt Lake City., Janecki T; University of Utah, Salt Lake City., Freimer M; Ohio State University, Columbus., Elsheikh B; Ohio State University, Columbus., Matisak P; Ohio State University, Columbus., Genge A; Montreal Neurological Institute, Montreal, Quebec, Canada., Guidon A; Massachusetts General Hospital, Boston., David W; Massachusetts General Hospital, Boston., Habib AA; University of California, Irvine, Orange., Mathew V; University of California, Irvine, Orange., Mozaffar T; University of California, Irvine, Orange., Hinton JL; Infirmary Health, Mobile, Alabama., Hewitt W; Infirmary Health, Mobile, Alabama., Barnett D; Infirmary Health, Mobile, Alabama., Sullivan P; Infirmary Health, Mobile, Alabama., Ho D; Lahey Hospital, Burlington, Massachusetts., Howard JF Jr; University of North Carolina, Chapel Hill., Traub RE; University of North Carolina, Chapel Hill., Chopra M; University of North Carolina, Chapel Hill., Kaminski HJ; George Washington University, Washington, DC., Aly R; George Washington University, Washington, DC., Bayat E; George Washington University, Washington, DC., Abu-Rub M; George Washington University, Washington, DC., Khan S; University of Texas Southwestern, Dallas, Irving., Lange D; Hospital for Special Surgery, New York, New York., Holzberg S; Hospital for Special Surgery, New York, New York., Khatri B; Center for Neurological Disorders, St Francis Hospital at Ascension, Milwaukee, Wisconsin., Lindman E; Center for Neurological Disorders, St Francis Hospital at Ascension, Milwaukee, Wisconsin., Olapo T; Center for Neurological Disorders, St Francis Hospital at Ascension, Milwaukee, Wisconsin., Sershon LM; Center for Neurological Disorders, St Francis Hospital at Ascension, Milwaukee, Wisconsin., Lisak RP; Wayne State University, Detroit, Michigan., Bernitsas E; Wayne State University, Detroit, Michigan., Jia K; Wayne State University, Detroit, Michigan., Malik R; Rush University, Chicago, Illinois., Lewis-Collins TD; Rush University, Chicago, Illinois., Nicolle M; London Health Sciences Center, London, Ontario, Canada., Nowak RJ; Yale School of Medicine, New Haven, Connecticut., Sharma A; Yale School of Medicine, New Haven, Connecticut., Roy B; Yale School of Medicine, New Haven, Connecticut., Nye J; Yale School of Medicine, New Haven, Connecticut., Pulley M; University of Florida, Jacksonville., Berger A; University of Florida, Jacksonville., Shabbir Y; University of Florida, Jacksonville., Sachdev A; Michigan State University, East Lansing., Patterson K; Michigan State University, East Lansing., Siddiqi Z; University of Alberta, Edmonton, Alberta, Canada., Sivak M; Mount Sinai Hospital, New York, New York., Bratton J; Mount Sinai Hospital, New York, New York., Small G; Allegheny Neurological Associates, Pittsburgh, Pennsylvania., Kohli A; Allegheny Neurological Associates, Pittsburgh, Pennsylvania., Fetter M; Allegheny Neurological Associates, Pittsburgh, Pennsylvania., Vu T; University of South Florida, Tampa., Lam L; University of South Florida, Tampa., Harvey B; University of South Florida, Tampa., Wolfe GI; University at Buffalo, Buffalo, New York., Silvestri N; University at Buffalo, Buffalo, New York., Patrick K; University at Buffalo, Buffalo, New York., Zakalik K; University at Buffalo, Buffalo, New York., Duda PW; Ra Pharmaceuticals Inc, Cambridge, Massachusetts., MacDougall J; Ra Pharmaceuticals Inc, Cambridge, Massachusetts., Farzaneh-Far R; Ra Pharmaceuticals Inc, Cambridge, Massachusetts., Pontius A; Ra Pharmaceuticals Inc, Cambridge, Massachusetts., Hoarty M; Ra Pharmaceuticals Inc, Cambridge, Massachusetts.
Corporate Authors: Zilucoplan MG Study Group
Source: JAMA neurology [JAMA Neurol] 2020 May 01; Vol. 77 (5), pp. 582-592.
Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2168-6157
DOI:10.1001/jamaneurol.2019.5125