Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.
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| Title: | Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy. |
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| Authors: | Yin L; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Masuyer G; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Zhang S; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Zhang J; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Miyashita SI; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America., Burgin D; Ipsen Bioinnovation, Abingdon, United Kingdom., Lovelock L; Ipsen Bioinnovation, Abingdon, United Kingdom., Coker SF; Ipsen Bioinnovation, Abingdon, United Kingdom., Fu TM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, United States of America., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Dong M; Department of Urology, Boston Children's Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America. |
| Source: | PLoS biology [PLoS Biol] 2020 Mar 17; Vol. 18 (3), pp. e3000618. Date of Electronic Publication: 2020 Mar 17 (Print Publication: 2020). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1545-7885 |
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| DOI: | 10.1371/journal.pbio.3000618 |
