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A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.

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Title: A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.
Authors: Maher TM; Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Simpson JK; GlaxoSmithKline Research and Development, Stevenage, UK., Porter JC; University College London Hospital, London, UK., Wilson FJ; GlaxoSmithKline Research and Development, Stevenage, UK., Chan R; GlaxoSmithKline Research and Development, Stevenage, UK., Eames R; GlaxoSmithKline Research and Development, Stevenage, UK., Cui Y; GlaxoSmithKline Research and Development, Stevenage, UK., Siederer S; GlaxoSmithKline Research and Development, Stevenage, UK., Parry S; GlaxoSmithKline Research and Development, Stevenage, UK., Kenny J; GlaxoSmithKline Research and Development, Stevenage, UK., Slack RJ; GlaxoSmithKline Research and Development, Stevenage, UK., Sahota J; University College London Hospital, London, UK., Paul L; Royal Brompton Hospital, London, UK., Saunders P; Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Molyneaux PL; Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Lukey PT; GlaxoSmithKline Research and Development, Stevenage, UK., Rizzo G; Invicro, A Konica Minolta Company, London, UK., Searle GE; Invicro, A Konica Minolta Company, London, UK., Marshall RP; GlaxoSmithKline Research and Development, Stevenage, UK., Saleem A; Invicro, A Konica Minolta Company, London, UK., Kang'ombe AR; GlaxoSmithKline Research and Development, Stevenage, UK., Fairman D; GlaxoSmithKline Research and Development, Stevenage, UK., Fahy WA; GlaxoSmithKline Research and Development, Stevenage, UK., Vahdati-Bolouri M; GlaxoSmithKline Research and Development, Stevenage, UK. mitra.x.vahdati-bolouri@gsk.com.
Source: Respiratory research [Respir Res] 2020 Mar 26; Vol. 21 (1), pp. 75. Date of Electronic Publication: 2020 Mar 26.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Maher+TM%22">Maher TM</searchLink>; Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Simpson+JK%22">Simpson JK</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Porter+JC%22">Porter JC</searchLink>; University College London Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+FJ%22">Wilson FJ</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Chan+R%22">Chan R</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Eames+R%22">Eames R</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Cui+Y%22">Cui Y</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Siederer+S%22">Siederer S</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Parry+S%22">Parry S</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Kenny+J%22">Kenny J</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Slack+RJ%22">Slack RJ</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Sahota+J%22">Sahota J</searchLink>; University College London Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Paul+L%22">Paul L</searchLink>; Royal Brompton Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Saunders+P%22">Saunders P</searchLink>; Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Molyneaux+PL%22">Molyneaux PL</searchLink>; Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lukey+PT%22">Lukey PT</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Rizzo+G%22">Rizzo G</searchLink>; Invicro, A Konica Minolta Company, London, UK.<br /><searchLink fieldCode="AU" term="%22Searle+GE%22">Searle GE</searchLink>; Invicro, A Konica Minolta Company, London, UK.<br /><searchLink fieldCode="AU" term="%22Marshall+RP%22">Marshall RP</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Saleem+A%22">Saleem A</searchLink>; Invicro, A Konica Minolta Company, London, UK.<br /><searchLink fieldCode="AU" term="%22Kang'ombe+AR%22">Kang'ombe AR</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Fairman+D%22">Fairman D</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Fahy+WA%22">Fahy WA</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Vahdati-Bolouri+M%22">Vahdati-Bolouri M</searchLink>; GlaxoSmithKline Research and Development, Stevenage, UK. mitra.x.vahdati-bolouri@gsk.com.
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  Data: <searchLink fieldCode="JN" term="%22101090633%22">Respiratory research</searchLink> [Respir Res] 2020 Mar 26; Vol. 21 (1), pp. 75. <i>Date of Electronic Publication: </i>2020 Mar 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101090633 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1465-993X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214659921%22">14659921 </searchLink><i>NLM ISO Abbreviation: </i>Respir Res <i>Subsets: </i>MEDLINE
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