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Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.

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Title: Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
Authors: Fell JB; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Fischer JP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Baer BR; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Blake JF; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Bouhana K; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Briere DM; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Brown KD; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Burgess LE; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Burns AC; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Burkard MR; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Chiang H; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Chicarelli MJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Cook AW; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Gaudino JJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Hallin J; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Hanson L; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Hartley DP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Hicken EJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Hingorani GP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Hinklin RJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Mejia MJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Olson P; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Otten JN; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Rhodes SP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Rodriguez ME; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Savechenkov P; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Smith DJ; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Sudhakar N; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Sullivan FX; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Tang TP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Vigers GP; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Wollenberg L; Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States., Christensen JG; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States., Marx MA; Mirati Therapeutics, 9393 Towne Centre Drive, Suite 200, San Diego, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2020 Jul 09; Vol. 63 (13), pp. 6679-6693. Date of Electronic Publication: 2020 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.9b02052