An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
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| Title: | An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. |
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| Authors: | Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. sheahan@email.unc.edu rbaric@email.unc.edu., Sims AC; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zhou S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Graham RL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Pruijssers AJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Agostini ML; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dinnon KH 3rd; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Stevens LJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Chappell JD; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Lu X; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hughes TM; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., George AS; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hill CS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Montgomery SA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA., Brown AJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bluemling GR; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA., Natchus MG; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Saindane M; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Kolykhalov AA; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA., Painter G; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322, USA., Harcourt J; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Tamin A; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Thornburg NJ; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Swanstrom R; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Denison MR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. sheahan@email.unc.edu rbaric@email.unc.edu.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2020 Apr 29; Vol. 12 (541). Date of Electronic Publication: 2020 Apr 06. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.abb5883 |
