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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.

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Title: An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Authors: Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. sheahan@email.unc.edu rbaric@email.unc.edu., Sims AC; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zhou S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Graham RL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Pruijssers AJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Agostini ML; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dinnon KH 3rd; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Stevens LJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Chappell JD; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Lu X; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hughes TM; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., George AS; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hill CS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Montgomery SA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA., Brown AJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bluemling GR; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA., Natchus MG; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Saindane M; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA., Kolykhalov AA; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA., Painter G; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322, USA., Harcourt J; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Tamin A; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Thornburg NJ; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Swanstrom R; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Denison MR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. sheahan@email.unc.edu rbaric@email.unc.edu.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Source: Science translational medicine [Sci Transl Med] 2020 Apr 29; Vol. 12 (541). Date of Electronic Publication: 2020 Apr 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
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  Data: <searchLink fieldCode="AU" term="%22Sheahan+TP%22">Sheahan TP</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. sheahan@email.unc.edu rbaric@email.unc.edu.<br /><searchLink fieldCode="AU" term="%22Sims+AC%22">Sims AC</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+S%22">Zhou S</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Graham+RL%22">Graham RL</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Pruijssers+AJ%22">Pruijssers AJ</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Agostini+ML%22">Agostini ML</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Leist+SR%22">Leist SR</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Schäfer+A%22">Schäfer A</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Dinnon+KH+3rd%22">Dinnon KH 3rd</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+LJ%22">Stevens LJ</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Chappell+JD%22">Chappell JD</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Hughes+TM%22">Hughes TM</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22George+AS%22">George AS</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Hill+CS%22">Hill CS</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Montgomery+SA%22">Montgomery SA</searchLink>; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Brown+AJ%22">Brown AJ</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Bluemling+GR%22">Bluemling GR</searchLink>; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Natchus+MG%22">Natchus MG</searchLink>; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Saindane+M%22">Saindane M</searchLink>; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Kolykhalov+AA%22">Kolykhalov AA</searchLink>; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Painter+G%22">Painter G</searchLink>; Emory Institute of Drug Development (EIDD), Emory University, Atlanta, GA 30322, USA.; Drug Innovation Ventures at Emory (DRIVE), Atlanta, GA 30322, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Harcourt+J%22">Harcourt J</searchLink>; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Tamin+A%22">Tamin A</searchLink>; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Thornburg+NJ%22">Thornburg NJ</searchLink>; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Swanstrom+R%22">Swanstrom R</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Denison+MR%22">Denison MR</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Baric+RS%22">Baric RS</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. sheahan@email.unc.edu rbaric@email.unc.edu.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2020 Apr 29; Vol. 12 (541). <i>Date of Electronic Publication: </i>2020 Apr 06.
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