Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction.
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| Title: | Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction. |
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| Authors: | Post KL; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Belmadani M; Department of Psychiatry, University of British Columbia, Vancouver, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, Canada., Ganguly P; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Meili F; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Dingwall R; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., McDiarmid TA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Psychology, University of British Columbia, Vancouver, Canada., Meyers WM; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Herrington C; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Young BP; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Callaghan DB; Department of Psychiatry, University of British Columbia, Vancouver, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, Canada., Rogic S; Department of Psychiatry, University of British Columbia, Vancouver, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, Canada., Edwards M; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Niciforovic A; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Cau A; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Rankin CH; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Psychology, University of British Columbia, Vancouver, Canada., O'Connor TP; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Bamji SX; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Loewen CJR; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Allan DW; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada., Pavlidis P; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. paul@msl.ubc.ca.; Department of Psychiatry, University of British Columbia, Vancouver, Canada. paul@msl.ubc.ca.; Michael Smith Laboratories, University of British Columbia, Vancouver, Canada. paul@msl.ubc.ca., Haas K; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. kurt.haas@ubc.ca.; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada. kurt.haas@ubc.ca. |
| Source: | Nature communications [Nat Commun] 2020 Apr 29; Vol. 11 (1), pp. 2073. Date of Electronic Publication: 2020 Apr 29. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-020-15943-0 |
