Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP.

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Title: Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP.
Authors: Jachimowicz RD; University of Cologne,University Hospital Cologne, Cologne, Germany., Pieper L; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany., Reinke S; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany., Gontarewicz A; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany., Plütschow A; University of Cologneand University Hospital Cologne, German Hodgkin Study Group, Germany., Haverkamp H; University of Cologneand University Hospital Cologne, German Hodgkin Study Group, Germany., Frauenfeld L; Department of Pathology, University of Tübingen, Germany., Fend F; Department of Pathology, University of Tübingen, Germany., Overkamp M; Department of Pathology, University of Tübingen, Germany., Jochims F; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany., Thorns C; Department of Pathology, University Hospital Schleswig-Holstein, University of Lübeck, Germany., Leo Hansmann M; Department of Pathology, University Hospital Frankfurt, Germany., Möller P; Department of Pathology, University Hospital Ulm, Germany., Rosenwald A; Institute of Pathology, University of Würzburg, Comprehensive Cancer Center Mainfranken, Germany., Stein H; Pathodiagnostik, Berlin, Germany., Reinhardt HC; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, Germany., Borchmann P; University of Cologne, German Hodgkin Study Group, Cologne, Germany., von Tresckow B; University of Cologne, German Hodgkin Study Group, Cologne, Germany., Engert A; University of Cologne, German Hodgkin Study Group, Cologne, Germany., Klapper W; University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.
Source: Haematologica [Haematologica] 2021 Jun 01; Vol. 106 (6), pp. 1684-1692. Date of Electronic Publication: 2021 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1592-8721
DOI:10.3324/haematol.2019.243287