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Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.

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Title: Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
Authors: Kancharla P; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Dodean RA; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Li Y; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Pou S; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Pybus B; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Melendez V; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Read L; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Bane CE; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Vesely B; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Kreishman-Deitrick M; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Black C; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Li Q; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Sciotti RJ; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Olmeda R; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Luong TL; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Gaona H; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Potter B; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Sousa J; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Marcsisin S; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Caridha D; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Xie L; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Vuong C; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Zeng Q; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Zhang J; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Zhang P; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Lin H; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Butler K; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Roncal N; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Gaynor-Ohnstad L; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Leed SE; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Nolan C; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States., Ceja FG; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States., Rasmussen SA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Rosenthal PJ; Department of Medicine, University of California, San Francisco, San Francisco, California 94143, United States., Mu J; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, United States., Bayles BR; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.; Global Public Health Program, Dominican University of California, San Rafael, California 94901, United States., Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States., Reynolds KA; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States., Smilkstein MJ; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Riscoe MK; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States., Kelly JX; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2020 Jun 11; Vol. 63 (11), pp. 6179-6202. Date of Electronic Publication: 2020 May 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
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Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Sousa+J%22">Sousa J</searchLink>; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Marcsisin+S%22">Marcsisin S</searchLink>; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Caridha+D%22">Caridha D</searchLink>; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States.<br /><searchLink fieldCode="AU" term="%22Vuong+C%22">Vuong C</searchLink>; 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Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.<br /><searchLink fieldCode="AU" term="%22Tumwebaze+PK%22">Tumwebaze PK</searchLink>; Infectious Diseases Research Collaboration, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Rosenthal+PJ%22">Rosenthal PJ</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, California 94143, United States.<br /><searchLink fieldCode="AU" term="%22Mu+J%22">Mu J</searchLink>; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, United States.<br /><searchLink fieldCode="AU" term="%22Bayles+BR%22">Bayles BR</searchLink>; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.; Global Public Health Program, Dominican University of California, San Rafael, California 94901, United States.<br /><searchLink fieldCode="AU" term="%22Cooper+RA%22">Cooper RA</searchLink>; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.<br /><searchLink fieldCode="AU" term="%22Reynolds+KA%22">Reynolds KA</searchLink>; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.<br /><searchLink fieldCode="AU" term="%22Smilkstein+MJ%22">Smilkstein MJ</searchLink>; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Riscoe+MK%22">Riscoe MK</searchLink>; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+JX%22">Kelly JX</searchLink>; Department of Chemistry, Portland State University, Portland, Oregon 97201, United States.; Department of Veterans Affairs Medical Center, Portland, Oregon 97239, United States.
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