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Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.

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Title: Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
Authors: Claes F; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Rudyak S; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Leninskiy Prospekt, 14, Moscow 119991, Russia., Laird AS; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium.; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia., Louros N; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Beerten J; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., Debulpaep M; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., Michiels E; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., van der Kant R; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Van Durme J; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., De Baets G; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., Houben B; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Ramakers M; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Yuan K; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia., Gwee SSL; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia., Hernandez S; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium., Broersen K; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., Oliveberg M; Stockholm University, Department of Biochemistry and Biophysics, Frescativägen, 114 19 Stockholm, Sweden., Moahamed B; Universität Bremen, Fachbereich 2 Biologie/ Chemie, Postfach 330 440, Bremen, Germany., Kirstein J; Universität Bremen, Fachbereich 2 Biologie/ Chemie, Postfach 330 440, Bremen, Germany., Robberecht W; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium., Rousseau F; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Schymkowitz J; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
Source: Protein engineering, design & selection : PEDS [Protein Eng Des Sel] 2019 Dec 31; Vol. 32 (10), pp. 443-457.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101186484 Publication Model: Print Cited Medium: Internet ISSN: 1741-0134 (Electronic) Linking ISSN: 17410126 NLM ISO Abbreviation: Protein Eng Des Sel Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
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  Data: <searchLink fieldCode="AU" term="%22Claes+F%22">Claes F</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Rudyak+S%22">Rudyak S</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Leninskiy Prospekt, 14, Moscow 119991, Russia.<br /><searchLink fieldCode="AU" term="%22Laird+AS%22">Laird AS</searchLink>; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium.; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Louros+N%22">Louros N</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Beerten+J%22">Beerten J</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Debulpaep+M%22">Debulpaep M</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Michiels+E%22">Michiels E</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22van+der+Kant+R%22">van der Kant R</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Durme+J%22">Van Durme J</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands.<br /><searchLink fieldCode="AU" term="%22De+Baets+G%22">De Baets G</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Houben+B%22">Houben B</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Ramakers+M%22">Ramakers M</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Yuan+K%22">Yuan K</searchLink>; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Gwee+SSL%22">Gwee SSL</searchLink>; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Hernandez+S%22">Hernandez S</searchLink>; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Broersen+K%22">Broersen K</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Oliveberg+M%22">Oliveberg M</searchLink>; Stockholm University, Department of Biochemistry and Biophysics, Frescativägen, 114 19 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Moahamed+B%22">Moahamed B</searchLink>; Universität Bremen, Fachbereich 2 Biologie/ Chemie, Postfach 330 440, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Kirstein+J%22">Kirstein J</searchLink>; Universität Bremen, Fachbereich 2 Biologie/ Chemie, Postfach 330 440, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Robberecht+W%22">Robberecht W</searchLink>; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Rousseau+F%22">Rousseau F</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Schymkowitz+J%22">Schymkowitz J</searchLink>; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.
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