Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
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| Title: | Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V. |
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| Authors: | Claes F; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Rudyak S; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Leninskiy Prospekt, 14, Moscow 119991, Russia., Laird AS; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium.; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia., Louros N; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Beerten J; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., Debulpaep M; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., Michiels E; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., van der Kant R; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Van Durme J; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., De Baets G; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., Houben B; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Ramakers M; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Yuan K; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia., Gwee SSL; Center for Motor Neuron Disease Research, Department of Biomedical Science, Faculty of Medicine, Macquarie University, Balaclava Rd, Macquarie Park, Sydney NSW 2109, Australia., Hernandez S; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium., Broersen K; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; Applied Stem Cell Technologies, University of Twente, Technical Medical Centre, Drienerlolaan 5, Enschede, The Netherlands., Oliveberg M; Stockholm University, Department of Biochemistry and Biophysics, Frescativägen, 114 19 Stockholm, Sweden., Moahamed B; Universität Bremen, Fachbereich 2 Biologie/ Chemie, Postfach 330 440, Bremen, Germany., Kirstein J; Universität Bremen, Fachbereich 2 Biologie/ Chemie, Postfach 330 440, Bremen, Germany., Robberecht W; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Herestraat 49, Leuven, Belgium., Rousseau F; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium., Schymkowitz J; VIB Center for Brain & Disease Research, Switch Laboratory, Herestraat 49, Leuven, Belgium.; KU Leuven, Department of Cellular and Molecular Medicine, Switch Laboratory, Herestraat 49, Leuven, Belgium. |
| Source: | Protein engineering, design & selection : PEDS [Protein Eng Des Sel] 2019 Dec 31; Vol. 32 (10), pp. 443-457. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101186484 Publication Model: Print Cited Medium: Internet ISSN: 1741-0134 (Electronic) Linking ISSN: 17410126 NLM ISO Abbreviation: Protein Eng Des Sel Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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