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Chemoinformatic-Guided Engineering of Polyketide Synthases.

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Title: Chemoinformatic-Guided Engineering of Polyketide Synthases.
Authors: Zargar A; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, Fourth Floor, Emeryville, California 94608, United States., Lal R; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Valencia L; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Wang J; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Backman TWH; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Cruz-Morales P; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Kothari A; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Werts M; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Wong AR; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Bailey CB; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, Fourth Floor, Emeryville, California 94608, United States., Loubat A; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Liu Y; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Chen Y; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Chang S; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Benites VT; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States., Hernández AC; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Barajas JF; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States., Thompson MG; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Barcelos C; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Anayah R; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Martin HG; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States.; BCAM, Basque Center for Applied Mathematics, 48009 Bilbao, Spain., Mukhopadhyay A; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States., Petzold CJ; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States., Baidoo EEK; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States., Katz L; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, Fourth Floor, Emeryville, California 94608, United States., Keasling JD; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, Fourth Floor, Emeryville, California 94608, United States.; Department of Chemical & Biomolecular Engineering, University of California, Berkeley, California 94720, United States.; Department of Bioengineering, University of California, Berkeley, California 94720, United States.; Novo Nordisk Foundation Center for Biosustainability, Technical University Denmark, DK2970 Horsholm, Denmark.; Synthetic Biochemistry Center, Institute for Synthetic Biology, Shenzhen Institutes for Advanced Technologies, 518055 Shenzhen, China.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2020 Jun 03; Vol. 142 (22), pp. 9896-9901. Date of Electronic Publication: 2020 May 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Chemoinformatic-Guided Engineering of Polyketide Synthases.
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  Data: <searchLink fieldCode="AU" term="%22Zargar+A%22">Zargar A</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, Fourth Floor, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Lal+R%22">Lal R</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Valencia+L%22">Valencia L</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Backman+TWH%22">Backman TWH</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Cruz-Morales+P%22">Cruz-Morales P</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Kothari+A%22">Kothari A</searchLink>; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Werts+M%22">Werts M</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Wong+AR%22">Wong AR</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Bailey+CB%22">Bailey CB</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, Fourth Floor, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Loubat+A%22">Loubat A</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Chang+S%22">Chang S</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Benites+VT%22">Benites VT</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Hernández+AC%22">Hernández AC</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Barajas+JF%22">Barajas JF</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Thompson+MG%22">Thompson MG</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Barcelos+C%22">Barcelos C</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Anayah+R%22">Anayah R</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Martin+HG%22">Martin HG</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States.; BCAM, Basque Center for Applied Mathematics, 48009 Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Mukhopadhyay+A%22">Mukhopadhyay A</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.<br /><searchLink fieldCode="AU" term="%22Petzold+CJ%22">Petzold CJ</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Baidoo+EEK%22">Baidoo EEK</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; Department of Energy, Agile BioFoundry, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Katz+L%22">Katz L</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, Fourth Floor, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Keasling+JD%22">Keasling JD</searchLink>; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California 94608, United States.; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States.; QB3 Institute, University of California-Berkeley, 5885 Hollis Street, Fourth Floor, Emeryville, California 94608, United States.; Department of Chemical & Biomolecular Engineering, University of California, Berkeley, California 94720, United States.; Department of Bioengineering, University of California, Berkeley, California 94720, United States.; Novo Nordisk Foundation Center for Biosustainability, Technical University Denmark, DK2970 Horsholm, Denmark.; Synthetic Biochemistry Center, Institute for Synthetic Biology, Shenzhen Institutes for Advanced Technologies, 518055 Shenzhen, China.
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  Data: <searchLink fieldCode="JN" term="%227503056%22">Journal of the American Chemical Society</searchLink> [J Am Chem Soc] 2020 Jun 03; Vol. 142 (22), pp. 9896-9901. <i>Date of Electronic Publication: </i>2020 May 18.
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