Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.
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| Title: | Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. |
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| Authors: | Ntalla I; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Weng LC; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cartwright JH; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hall AW; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sveinbjornsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Tucker NR; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Choi SH; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chaffin MD; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roselli C; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Barnes MR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Mifsud B; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Cranley JJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Concas MP; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Gasparini P; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medicine, Surgery and Health Science, University of Trieste, Trieste, Italy., Boutin T; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Kolcic I; University of Split School of Medicine, Split, Croatia., Polasek O; University of Split School of Medicine, Split, Croatia.; Clinical Hospital Centre Split, Split, Croatia.; Psychiatric Hospital Sveti Ivan, Zagreb, Croatia., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Araujo NM; Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Lima-Costa MF; Rene Rachou Reserch Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil., Ribeiro ALP; Hospital das Clínicas e Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Souza RP; Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Tarazona-Santos E; Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Giedraitis V; Department of Public Health, Geriatrics, Uppsala University, Uppsala, Sweden., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK., Del Greco M F; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Foco L; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Gögele M; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Hicks AA; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK., Lind L; Medical Sciences, Uppsala University Hospital, Uppsala, Sweden., Lindgren CM; Nuffield Department of Medicine, Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK.; Nuffield Department of Medicine, The Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sundström J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Nelson CP; Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK., Riaz MB; Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK., Samani NJ; Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield Hospital, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK., Sinagra G; Cardiovascular Department, Azienda Ospedaliera Universitaria Integrata of Trieste, Trieste, Italy., Ulivi S; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center Tampere University, Tampere, Finland., Mishra PP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Dominiczak A; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Ryan K; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Shuldiner AR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Aeschbacher S; Cardiology Division, University Hospital, Basel, Switzerland., Conen D; Cardiology Division, University Hospital, Basel, Switzerland.; Population Health Research Institute, McMaster University, Hamilton, ON, Canada., Risch L; Institute of Clinical Chemistry, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.; Labormedizinisches Zentrum Dr. Risch, Vaduz, Liechtenstein.; Private University of the Principality of Liechtenstein, Triesen, Liechtenstein., Thériault S; Population Health Research Institute, McMaster University, Hamilton, ON, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec, QC, Canada., Hutri-Kähönen N; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center, Tampere University, Tampere, Finland.; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Barnes CLK; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Joshi PK; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Wilson JF; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Isaacs A; CARIM School for Cardiovascular Diseases, Maastricht Center for Systems Biology (MaCSBio), Department of Biochemistry, and Department of Physiology, Maastricht University, Maastricht, The Netherlands., Kors JA; Department of Medical Informatics Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Huang PL; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Mei H; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Wilson J; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Meitinger T; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Müller-Nurasyid M; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Peters A; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Waldenberger M; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., Rienstra M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van de Vegte YJ; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Genomics plc, Oxford, UK., Kääb S; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Schramm K; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Sinner MF; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany.; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany., Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA., Fatkin D; Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.; Cardiology Department, St. Vincent's Hospital, Darlinghurst, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Kensington, NSW, Australia., London B; Department of Cardiovascular Medicine, University of Iowa, Iowa City, IA, USA., Olesen M; Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Benjamin Shoemaker M; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Gustav Smith J; Department of Cardiology, Clinical Sciences, Wallenberg Center for Molecular Medicine, Lund University Diabetes Center, Lund University and Skane University Hospital, Lund, Sweden., Biggs ML; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Rice K; Department of Biostatistics, University of Washington, Seattle, WA, USA., Sotoodehnia N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Cardiology Division, University of Washington, Seattle, WA, USA., De Grandi A; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Pattaro C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK., Wouter Jukema J; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Macfarlane PW; Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Trompet S; Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Dörr M; DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.; Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany., Felix SB; DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.; Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany., Völker U; DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine and University of Greifswald, Greifswald, Germany., Weiss S; DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine and University of Greifswald, Greifswald, Germany., Havulinna AS; Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Jula A; Finnish Institute for Health and Welfare, Helsinki, Finland., Sääksjärvi K; Finnish Institute for Health and Welfare, Helsinki, Finland., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., Guo X; Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Heckbert SR; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA., Lin HJ; Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Rotter JI; Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Taylor KD; Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Yao J; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Maan AC; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Noordam R; Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Cucca F; Department of Biomedical Sciences, University of Sassari, Sassari, Italy., Ding J; Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA., Lakatta EG; Laboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA., Qian Y; Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD, USA., Tarasov KV; Laboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD, USA., Levy D; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.; National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA., Lin H; National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Newton-Cheh CH; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Human Genetic Research and Cardiovascular Research Center, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA., Lunetta KL; National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Murray AD; The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Stricker BH; Department of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Uitterlinden A; Human Genotyping Facility Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., van den Berg ME; Department of Epidemiology Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Haessler J; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Jackson RD; Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, OH, USA., Kooperberg C; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Peters U; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Reiner AP; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Whitsel EA; Departments of Epidemiology and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Boerwinkle E; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Ehret GB; Cardiology, Geneva University Hospitals, Geneva, Switzerland., Soliman EZ; Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA., Avery CL; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Kerr KF; Department of Biostatistics, University of Washington, Seattle, WA, USA., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Seyerle AA; Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, NC, USA., Stilp A; Department of Biostatistics, University of Washington, Seattle, WA, USA., Assa S; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Abdullah Said M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Yldau van der Ende M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Lambiase PD; Barts Heart Centre, St Bartholomews Hospital, London, UK.; Institute of Cardiovascular Science, University College London, London, UK., Orini M; Barts Heart Centre, St Bartholomews Hospital, London, UK.; Department of Mechanical Engineering, University College London, London, UK., Ramirez J; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Institute of Cardiovascular Science, University College London, London, UK., Van Duijvenboden S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Institute of Cardiovascular Science, University College London, London, UK., Arnar DO; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Sulem P; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Thorolfsdottir RB; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Benjamin EJ; National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Section of Cardiovascular Medicine and Section of Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Tinker A; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA., Jamshidi Y; Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's, University of London, London, UK., Lubitz SA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. slubitz@mgh.harvard.edu.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. slubitz@mgh.harvard.edu.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA. slubitz@mgh.harvard.edu., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.; National Institute for Health Research, Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk. |
| Source: | Nature communications [Nat Commun] 2020 May 21; Vol. 11 (1), pp. 2542. Date of Electronic Publication: 2020 May 21. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-020-15706-x |
