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A simple method for determining compound affinity and chemical yield from DNA-encoded library selections.

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Title: A simple method for determining compound affinity and chemical yield from DNA-encoded library selections.
Authors: Hall J; Structural Biology, Pfizer, 3200 Walnut Rd, Boulder, CO, 80301, USA. Electronic address: justin.hall@pfizer.com., Foley TL; Discovery Sciences, Pfizer, Eastern Point Rd, Groton, CT, 06340, USA., Chen Q; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Israel DI; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Xu Y; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Ford KK; Discovery Sciences, Pfizer, Eastern Point Rd, Groton, CT, 06340, USA., Xie P; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Fan J; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Wan J; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China.
Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 18; Vol. 527 (1), pp. 250-256. Date of Electronic Publication: 2020 May 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2104
DOI:10.1016/j.bbrc.2020.04.024