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Structure-Permeability Relationship of Semipeptidic Macrocycles-Understanding and Optimizing Passive Permeability and Efflux Ratio.

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Title: Structure-Permeability Relationship of Semipeptidic Macrocycles-Understanding and Optimizing Passive Permeability and Efflux Ratio.
Authors: Le Roux A; Department of Pharmacology-Physiology, Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec J1H 5N4, Canada., Blaise É; Department of Pharmacology-Physiology, Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec J1H 5N4, Canada., Boudreault PL; Department of Pharmacology-Physiology, Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec J1H 5N4, Canada., Comeau C; Department of Pharmacology-Physiology, Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec J1H 5N4, Canada., Doucet A; Department of Pharmacology-Physiology, Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec J1H 5N4, Canada., Giarrusso M; Department of Pharmacology-Physiology, Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec J1H 5N4, Canada., Collin MP; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Neubauer T; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Kölling F; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Göller AH; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Seep L; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Tshitenge DT; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Wittwer M; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Kullmann M; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Hillisch A; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Mittendorf J; Drug Discovery, Pharmaceuticals, Bayer AG, Wuppertal D-42096, Germany., Marsault E; Department of Pharmacology-Physiology, Institut de Pharmacologie de Sherbrooke, 3001, 12e av nord, Sherbrooke, Québec J1H 5N4, Canada.
Source: Journal of medicinal chemistry [J Med Chem] 2020 Jul 09; Vol. 63 (13), pp. 6774-6783. Date of Electronic Publication: 2020 May 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.0c00013