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Partitioning of cancer therapeutics in nuclear condensates.

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Title: Partitioning of cancer therapeutics in nuclear condensates.
Authors: Klein IA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Boija A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Afeyan LK; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hawken SW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fan M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Dall'Agnese A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Oksuz O; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Henninger JE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Shrinivas K; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sabari BR; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Sagi I; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Clark VE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Platt JM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Kar M; Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany., McCall PM; Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.; Center for Systems Biology Dresden, 01307 Dresden, Germany., Zamudio AV; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Manteiga JC; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Coffey EL; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Li CH; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hannett NM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Guo YE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Decker TM; Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA., Lee TI; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Zhang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Weng JK; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Taatjes DJ; Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA., Chakraborty A; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard Medical School, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sharp PA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chang YT; Department of Chemistry, Pohang University of Science and Technology, and Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea., Hyman AA; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.; Cluster of Excellence Physics of Life, Technical University of Dresden, 01062 Dresden, Germany., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. young@wi.mit.edu.
Source: Science (New York, N.Y.) [Science] 2020 Jun 19; Vol. 368 (6497), pp. 1386-1392.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.aaz4427