Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice.
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| Title: | Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice. |
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| Authors: | Eguchi A; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan. akieguchi@clin.medic.mie-u.ac.jp.; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. akieguchi@clin.medic.mie-u.ac.jp.; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. akieguchi@clin.medic.mie-u.ac.jp.; JST, PRETO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. akieguchi@clin.medic.mie-u.ac.jp., Yan R; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA., Pan SQ; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA., Wu R; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA., Kim J; Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA., Chen Y; Bioinformatics Services, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90007, USA., Ansong C; Pacific Northwest National Laboratory, Richland, WA, USA., Smith RD; Pacific Northwest National Laboratory, Richland, WA, USA., Tempaku M; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan., Ohno-Machado L; Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, USA., Takei Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan., Feldstein AE; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA., Tsukamoto H; Southern California Research Center for ALPD and Cirrhosis, Los Angeles, CA, USA. htsukamo@med.usc.edu.; Department of Pathology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu.; Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA. htsukamo@med.usc.edu. |
| Source: | Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2020 Jul; Vol. 98 (7), pp. 1021-1034. Date of Electronic Publication: 2020 Jun 18. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Springer International Country of Publication: Germany NLM ID: 9504370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1440 (Electronic) Linking ISSN: 09462716 NLM ISO Abbreviation: J Mol Med (Berl) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-1440 |
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| DOI: | 10.1007/s00109-020-01926-7 |
