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3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates.

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Title: 3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates.
Authors: Kasturi SP; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Rasheed MAU; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.; Division of Microbiology and Immunology and Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA, USA., Havenar-Daughton C; Division of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA, USA., Pham M; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Legere T; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Sher ZJ; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Kovalenkov Y; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Gumber S; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Huang JY; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Gottardo R; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Fulp W; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Sato A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Sawant S; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA., Stanfield-Oakley S; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Yates N; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA., LaBranche C; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Alam SM; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Tomaras G; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA., Ferrari G; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA., Montefiori D; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Wrammert J; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Villinger F; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.; New Iberia Research Center, University of Louisiana Lafayette, New Iberia, LA, USA., Tomai M; 3M Drug Delivery Systems, St. Paul, MN, USA., Vasilakos J; 3M Drug Delivery Systems, St. Paul, MN, USA., Fox CB; Infectious Disease Research Institute, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Reed SG; Infectious Disease Research Institute, Seattle, WA, USA.; HDT Bio, Seattle, WA, USA., Haynes BF; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Crotty S; Division of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego (UCSD), La Jolla, CA, USA., Ahmed R; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA. bpulend@stanford.edu rahmed@emory.edu.; Division of Microbiology and Immunology and Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA, USA., Pulendran B; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA. bpulend@stanford.edu rahmed@emory.edu.; Departments of Pathology and Microbiology & Immunology, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
Source: Science immunology [Sci Immunol] 2020 Jun 19; Vol. 5 (48).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates.
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  Data: <searchLink fieldCode="AU" term="%22Kasturi+SP%22">Kasturi SP</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rasheed+MAU%22">Rasheed MAU</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.; Division of Microbiology and Immunology and Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Havenar-Daughton+C%22">Havenar-Daughton C</searchLink>; Division of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pham+M%22">Pham M</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Legere+T%22">Legere T</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Sher+ZJ%22">Sher ZJ</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kovalenkov+Y%22">Kovalenkov Y</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gumber+S%22">Gumber S</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+JY%22">Huang JY</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gottardo+R%22">Gottardo R</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Fulp+W%22">Fulp W</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sato+A%22">Sato A</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sawant+S%22">Sawant S</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA.<br /><searchLink fieldCode="AU" term="%22Stanfield-Oakley+S%22">Stanfield-Oakley S</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Yates+N%22">Yates N</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA.<br /><searchLink fieldCode="AU" term="%22LaBranche+C%22">LaBranche C</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Alam+SM%22">Alam SM</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Tomaras+G%22">Tomaras G</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ferrari+G%22">Ferrari G</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA.<br /><searchLink fieldCode="AU" term="%22Montefiori+D%22">Montefiori D</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wrammert+J%22">Wrammert J</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Villinger+F%22">Villinger F</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.; New Iberia Research Center, University of Louisiana Lafayette, New Iberia, LA, USA.<br /><searchLink fieldCode="AU" term="%22Tomai+M%22">Tomai M</searchLink>; 3M Drug Delivery Systems, St. Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Vasilakos+J%22">Vasilakos J</searchLink>; 3M Drug Delivery Systems, St. Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Fox+CB%22">Fox CB</searchLink>; Infectious Disease Research Institute, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Reed+SG%22">Reed SG</searchLink>; Infectious Disease Research Institute, Seattle, WA, USA.; HDT Bio, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Haynes+BF%22">Haynes BF</searchLink>; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Crotty+S%22">Crotty S</searchLink>; Division of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego (UCSD), La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ahmed+R%22">Ahmed R</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA. bpulend@stanford.edu rahmed@emory.edu.; Division of Microbiology and Immunology and Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Pulendran+B%22">Pulendran B</searchLink>; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA. bpulend@stanford.edu rahmed@emory.edu.; Departments of Pathology and Microbiology & Immunology, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101688624%22">Science immunology</searchLink> [Sci Immunol] 2020 Jun 19; Vol. 5 (48).
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