3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates.
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| Title: | 3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates. |
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| Authors: | Kasturi SP; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Rasheed MAU; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.; Division of Microbiology and Immunology and Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA, USA., Havenar-Daughton C; Division of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA, USA., Pham M; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Legere T; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Sher ZJ; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Kovalenkov Y; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Gumber S; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Huang JY; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Gottardo R; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Fulp W; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Sato A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Sawant S; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA., Stanfield-Oakley S; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Yates N; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA., LaBranche C; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Alam SM; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Tomaras G; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA., Ferrari G; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.; Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA., Montefiori D; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Wrammert J; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA., Villinger F; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.; New Iberia Research Center, University of Louisiana Lafayette, New Iberia, LA, USA., Tomai M; 3M Drug Delivery Systems, St. Paul, MN, USA., Vasilakos J; 3M Drug Delivery Systems, St. Paul, MN, USA., Fox CB; Infectious Disease Research Institute, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Reed SG; Infectious Disease Research Institute, Seattle, WA, USA.; HDT Bio, Seattle, WA, USA., Haynes BF; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA., Crotty S; Division of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego (UCSD), La Jolla, CA, USA., Ahmed R; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA. bpulend@stanford.edu rahmed@emory.edu.; Division of Microbiology and Immunology and Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA, USA., Pulendran B; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA. bpulend@stanford.edu rahmed@emory.edu.; Departments of Pathology and Microbiology & Immunology, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA. |
| Source: | Science immunology [Sci Immunol] 2020 Jun 19; Vol. 5 (48). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.abb1025 |
