High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling.
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| Title: | High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. |
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| Authors: | Strand KA; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora., Lu S; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora., Mutryn MF; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora., Li L; School of Pharmacy and Pharmaceutical Sciences (L.L., Q.Z., D.V.L.), University of Colorado, Anschutz Medical Campus, Aurora., Zhou Q; School of Pharmacy and Pharmaceutical Sciences (L.L., Q.Z., D.V.L.), University of Colorado, Anschutz Medical Campus, Aurora., Enyart BT; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; Division of Cardiology, Department of Medicine (B.T.E., K.S.M., K.A.K.), University of Colorado, Anschutz Medical Campus, Aurora., Jolly AJ; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora., Dubner AM; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora., Moulton KS; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; Division of Cardiology, Department of Medicine (B.T.E., K.S.M., K.A.K.), University of Colorado, Anschutz Medical Campus, Aurora., Nemenoff RA; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora., Koch KA; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; Division of Cardiology, Department of Medicine (B.T.E., K.S.M., K.A.K.), University of Colorado, Anschutz Medical Campus, Aurora., LaBarbera DV; School of Pharmacy and Pharmaceutical Sciences (L.L., Q.Z., D.V.L.), University of Colorado, Anschutz Medical Campus, Aurora., Weiser-Evans MCM; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora. |
| Source: | Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Aug; Vol. 40 (8), pp. 1854-1869. Date of Electronic Publication: 2020 Jun 25. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 32580634 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Strand+KA%22">Strand KA</searchLink>; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Mutryn+MF%22">Mutryn MF</searchLink>; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; School of Pharmacy and Pharmaceutical Sciences (L.L., Q.Z., D.V.L.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; School of Pharmacy and Pharmaceutical Sciences (L.L., Q.Z., D.V.L.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Enyart+BT%22">Enyart BT</searchLink>; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; Division of Cardiology, Department of Medicine (B.T.E., K.S.M., K.A.K.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Jolly+AJ%22">Jolly AJ</searchLink>; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Dubner+AM%22">Dubner AM</searchLink>; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Moulton+KS%22">Moulton KS</searchLink>; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; Division of Cardiology, Department of Medicine (B.T.E., K.S.M., K.A.K.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Nemenoff+RA%22">Nemenoff RA</searchLink>; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Koch+KA%22">Koch KA</searchLink>; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; Division of Cardiology, Department of Medicine (B.T.E., K.S.M., K.A.K.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22LaBarbera+DV%22">LaBarbera DV</searchLink>; School of Pharmacy and Pharmaceutical Sciences (L.L., Q.Z., D.V.L.), University of Colorado, Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Weiser-Evans+MCM%22">Weiser-Evans MCM</searchLink>; From the Division of Renal Diseases and Hypertension, Department of Medicine (K.A.S., S.L., M.F.M., A.J.J., A.M.D., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.; School of Medicine, Consortium for Fibrosis Research & Translation (B.T.E., K.S.M., R.A.N., K.A.K., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229505803%22">Arteriosclerosis, thrombosis, and vascular biology</searchLink> [Arterioscler Thromb Vasc Biol] 2020 Aug; Vol. 40 (8), pp. 1854-1869. <i>Date of Electronic Publication: </i>2020 Jun 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9505803 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1524-4636 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210795642%22">10795642 </searchLink><i>NLM ISO Abbreviation: </i>Arterioscler Thromb Vasc Biol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=32580634 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1161/ATVBAHA.120.314458 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1854 Titles: – TitleFull: High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Strand KA – PersonEntity: Name: NameFull: Lu S – PersonEntity: Name: NameFull: Mutryn MF – PersonEntity: Name: NameFull: Li L – PersonEntity: Name: NameFull: Zhou Q – PersonEntity: Name: NameFull: Enyart BT – PersonEntity: Name: NameFull: Jolly AJ – PersonEntity: Name: NameFull: Dubner AM – PersonEntity: Name: NameFull: Moulton KS – PersonEntity: Name: NameFull: Nemenoff RA – PersonEntity: Name: NameFull: Koch KA – PersonEntity: Name: NameFull: LaBarbera DV – PersonEntity: Name: NameFull: Weiser-Evans MCM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2020 Aug Type: published Y: 2020 Identifiers: – Type: issn-electronic Value: 1524-4636 Numbering: – Type: volume Value: 40 – Type: issue Value: 8 Titles: – TitleFull: Arteriosclerosis, thrombosis, and vascular biology Type: main |
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