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Safety and efficacy of N-acetylcysteine in hospitalized patients with HIV-associated tuberculosis: An open-label, randomized, phase II trial (RIPENACTB Study).

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Title: Safety and efficacy of N-acetylcysteine in hospitalized patients with HIV-associated tuberculosis: An open-label, randomized, phase II trial (RIPENACTB Study).
Authors: Safe IP; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil., Lacerda MVG; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.; Instituto Leônidas & Maria Deane, Fiocruz, Manaus, Brazil., Printes VS; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil., Praia Marins AF; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil., Rebelo Rabelo AL; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil., Costa AA; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil., Tavares MA; Universidade Federal do Amazonas, Manaus, Brazil., Jesus JS; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil., Souza AB; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil., Beraldi-Magalhães F; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil., Neves CP; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil., Monteiro WM; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil., Sampaio VS; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil., Amaral EP; Immunobiology Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Gomes RS; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil., Andrade BB; Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil.; Multinational Organization Network Sponsoring Translational and Epidemiological Research, (MONSTER) Initiative, Salvador, Brazil.; Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil.; Curso de Medicina, Faculdade de Tecnologia e Ciências, Salvador, Brazil.; Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town (UCT), Cape Town, South Africa.; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States of America., Cordeiro-Santos M; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.
Source: PloS one [PLoS One] 2020 Jun 26; Vol. 15 (6), pp. e0235381. Date of Electronic Publication: 2020 Jun 26 (Print Publication: 2020).
Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and efficacy of N-acetylcysteine in hospitalized patients with HIV-associated tuberculosis: An open-label, randomized, phase II trial (RIPENACTB Study).
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  Data: <searchLink fieldCode="AU" term="%22Safe+IP%22">Safe IP</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Lacerda+MVG%22">Lacerda MVG</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.; Instituto Leônidas & Maria Deane, Fiocruz, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Printes+VS%22">Printes VS</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Praia+Marins+AF%22">Praia Marins AF</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Rebelo+Rabelo+AL%22">Rebelo Rabelo AL</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+AA%22">Costa AA</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Tavares+MA%22">Tavares MA</searchLink>; Universidade Federal do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Jesus+JS%22">Jesus JS</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+AB%22">Souza AB</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Beraldi-Magalhães+F%22">Beraldi-Magalhães F</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Neves+CP%22">Neves CP</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Monteiro+WM%22">Monteiro WM</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Sampaio+VS%22">Sampaio VS</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Amaral+EP%22">Amaral EP</searchLink>; Immunobiology Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Gomes+RS%22">Gomes RS</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Andrade+BB%22">Andrade BB</searchLink>; Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil.; Multinational Organization Network Sponsoring Translational and Epidemiological Research, (MONSTER) Initiative, Salvador, Brazil.; Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil.; Curso de Medicina, Faculdade de Tecnologia e Ciências, Salvador, Brazil.; Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town (UCT), Cape Town, South Africa.; Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States of America.<br /><searchLink fieldCode="AU" term="%22Cordeiro-Santos+M%22">Cordeiro-Santos M</searchLink>; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.
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