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A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation.

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Bibliographic Details
Title: A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation.
Authors: Ray D; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore; debleena.ray@duke-nus.edu.sg david.epstein@duke-nus.edu.sg., Yun YC; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore., Idris M; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore., Cheng S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore.; Centre for Computational Biology, Duke-NUS Medical School, 165897 Singapore, Singapore., Boot A; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore.; Centre for Computational Biology, Duke-NUS Medical School, 165897 Singapore, Singapore., Iain TBH; Division of Medical Oncology, National Cancer Centre, 169610 Singapore, Singapore., Rozen SG; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore.; Centre for Computational Biology, Duke-NUS Medical School, 165897 Singapore, Singapore., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore., Epstein DM; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore; debleena.ray@duke-nus.edu.sg david.epstein@duke-nus.edu.sg.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 14; Vol. 117 (28), pp. 16391-16400. Date of Electronic Publication: 2020 Jun 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2002499117